NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=LAST93;
DOI=10.1111/j.1574-6968.1998.tb12966.x; PubMed=9570125 [NCBI, ExPASy, EBI, Israel, Japan]
Keon J.P.R., Hargreaves J.A.;
"Isolation and heterologous expression of a gene encoding 4-hydroxyphenylpyruvate dioxygenase from the wheat leaf-spot pathogen, Mycosphaerella graminicola.";
FEMS Microbiol. Lett. 161:337-343(1998).

Comments

CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O₂ = homogentisate + CO₂.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6 .
SIMILARITY: Belongs to the 4HPPD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF038152; AAC15884.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P80064; 1CJX. [HSSP ENTRY / PDB]

ModBase

O42764.

Family and domain databases

InterPro

IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.

PANTHER

PTHR11959; HPP_dOase; 1.

Pfam

PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF009283; HPP_dOase; 1.

TIGR01263; 4HPPD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 419`	`419`	`4-hydroxyphenylpyruvate dioxygenase.`	`PRO_0000088405`
`METAL`	`221 221`		`Iron (By similarity).`
`METAL`	`304 304`		`Iron (By similarity).`
`METAL`	`387 387`		`Iron (By similarity).`

Sequence information

Length: 419 AA [This is the length of the unprocessed precursor]

Molecular weight: 46740 Da [This is the MW of the unprocessed precursor]

CRC64: 07951CCE0CB50EE3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAPGALLVTS QNGRTSPLYD SDGYVPAPAA LVVGGEVNYR GYHHAEWWVG NAKQVAQFYI 

        70         80         90        100        110        120 
TRMGFEPVAH KGLETGSRFF ASHVVQNNGV RFVFTSPVRS SARQTLKAAP LADQARLDEM 

       130        140        150        160        170        180 
YDHLDKHGDG VKDVAFEVDD VLAVYENAVA NGAESVSSPH TDSCDEGDVI SAAIKTYGDT 

       190        200        210        220        230        240 
THTFIQRTTY TGPFLPGYRS CTTVDSANKF LPPVNLEAID HCVGNQDWDE MSDACDFYER 

       250        260        270        280        290        300 
CLGFHRFWSV DDKDICTEFS ALKSIVMSSP NQVVKMPINE PAHGKKKSQI EEYVDFYNGP 

       310        320        330        340        350        360 
GVQHIALRTP NIIEAVSNLR SRGVEFISVP DTYYENMRLR LKAAGMKLEE SFDIIQKLNI 

       370        380        390        400        410 
LIDFDEGGYL LQLFTKPLMD RPTVFIEIIQ RNNFDGFGAG NFKSLFEAIE REQDLRGNL

O42764 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools