[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1006/bbrc.1997.6816; PubMed=9207184 [NCBI, ExPASy, EBI, Israel, Japan] Beppu H., Minowa O., Miyazono K., Kawabata M.; "cDNA cloning and genomic organization of the mouse BMP type II receptor."; Biochem. Biophys. Res. Commun. 235:499-504(1997).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. Whitaker G.B., Koenig B.B., Ting J., Tiesman J.P., Limberg A.L., Grant R.A., Begley K.B., Rosenbaum J.S.; "Identification of BMP receptor complexes with differential signaling properties and ligand binding profiles."; Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF003942; AAB63042.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U78048; AAB87638.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

JC5527; JC5527.

NP_031587.1; -.

3D structure databases

HSSP

P36897; 1IAS. [HSSP ENTRY / PDB]

SMR

O35607; 33-131.

ModBase

O35607.

Protein-protein interaction databases

IntAct

O35607; -.

PTM databases

PhosphoSite

O35607; -.

Organism-specific databases

MGI

MGI:1095407; Bmpr2.

Gene expression databases

ArrayExpress

O35607; -.

GermOnline

ENSMUSG00000067336; Mus musculus.

Ontologies

GO:0009986;	Cellular component: cell surface (inferred from direct assay from MGI).
GO:0048286;	Biological process: alveolus development (inferred from mutant phenotype from UniProtKB).
GO:0009952;	Biological process: anterior/posterior pattern formation (inferred from mutant phenotype from MGI).
GO:0030509;	Biological process: BMP signaling pathway (inferred from mutant phenotype from MGI).
GO:0001707;	Biological process: mesoderm formation (inferred from mutant phenotype from MGI).
GO:0045906;	Biological process: negative regulation of vasoconstriction (inferred from mutant phenotype from UniProtKB).
GO:0014916;	Biological process: regulation of lung blood pressure (inferred from mutant phenotype from UniProtKB).
GO:0048010;	Biological process: vascular endothelial growth factor receptor signaling pathway (inferred from mutant phenotype from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR000472; Activin_rcpt.
IPR015770; BMPRII.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.

PANTHER

PTHR23255:SF12; BMPRII; 1.

Pfam

PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

BLOCKS

O35607.

Genome annotation databases

Ensembl

ENSMUSG00000067336; Mus musculus. [Contig view]

GeneID

12168; -.

KEGG

mmu:12168; -.

Phylogenomic databases

HOGENOM

O35607; -.

HOVERGEN

O35607; -.

Other

Bmpr2; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 26`	`26`	`Potential.`
`CHAIN`	`27 1038`	`1012`	`Bone morphogenetic protein receptor type-2.`	`PRO_0000024416`
`TOPO_DOM`	`27 150`	`124`	`Extracellular (Potential).`
`TRANSMEM`	`151 171`	`21`	`Potential.`
`TOPO_DOM`	`172 1038`	`867`	`Cytoplasmic (Potential).`
`DOMAIN`	`203 504`	`302`	`Protein kinase.`
`NP_BIND`	`209 217`	`9`	`ATP (By similarity).`
`COMPBIAS`	`191 194`	`4`	`Poly-Ala.`
`COMPBIAS`	`547 550`	`4`	`Poly-Ser.`
`COMPBIAS`	`610 618`	`9`	`Poly-Thr.`
`COMPBIAS`	`901 908`	`8`	`Poly-Asn.`
`ACT_SITE`	`333 333`		`Proton acceptor (By similarity).`
`BINDING`	`230 230`		`ATP (By similarity).`
`CARBOHYD`	`55 55`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`110 110`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`126 126`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`34 66`		`By similarity.`
`DISULFID`	`94 117`		`By similarity.`

Sequence information

Length: 1038 AA [This is the length of the unprocessed precursor]

Molecular weight: 115020 Da [This is the MW of the unprocessed precursor]

CRC64: 4106945DC63250E1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 

        70         80         90        100        110        120 
SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 

       130        140        150        160        170        180 
DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 

       190        200        210        220        230        240 
QGLHSMNMME AAAAEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 

       250        260        270        280        290        300 
INEKNIYRVP LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 

       310        320        330        340        350        360 
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS DFGLSMRLTG 

       370        380        390        400        410        420 
NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEVFMRC 

       430        440        450        460        470        480 
TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 

       490        500        510        520        530        540 
EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI 

       550        560        570        580        590        600 
GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 

       610        620        630        640        650        660 
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG PTPVCLQLTE 

       670        680        690        700        710        720 
EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ 

       730        740        750        760        770        780 
QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN 

       790        800        810        820        830        840 
LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA 

       850        860        870        880        890        900 
HRSQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 

       910        920        930        940        950        960 
NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD GSSIQIGEST 

       970        980        990       1000       1010       1020 
QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV NNNGSDRAVH SKSSTAVYLA 

      1030 
EGGTATTTVS KDIGMNCL

O35607 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools