NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=O8:K40 / 2775;
PubMed=9383197 [NCBI, ExPASy, EBI, Israel, Japan]
Amor P.A., Whitfield C.;
"Molecular and functional analysis of genes required for expression of group IB K antigens in Escherichia coli: characterization of the his-region containing gene clusters for multiple cell-surface polysaccharides.";
Mol. Microbiol. 26:145-161(1997).

Comments

CATALYTIC ACTIVITY: UDP-glucose + 2 NAD⁺ + H₂O = UDP-glucuronate + 2 NADH.
PATHWAY: Nucleotide-sugar biosynthesis; UDP-glucuronate biosynthesis; UDP-glucuronate from UDP-glucose: step 1/1 .
PATHWAY: Context: Lipid A modification with 4-amino-4-deoxy-L-arabinose .
PTM: Phosphorylated on a tyrosine residue. It results in a significant increase of the dehydrogenase activity (By similarity).
SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U78086; AAC45829.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q07172; 1DLI. [HSSP ENTRY / PDB]

ModBase

O33952.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR017476; Nucleotide_sugar_DH.
IPR014027; UDP-Glc/GDP-Man_DHase_C.
IPR014026; UDP-Glc/GDP-Man_DHase_dimer.
IPR014028; UDP-Glc/GDP-Man_DHase_dimer-bd.
IPR001732; UDP-Glc/GDP-Man_DHase_N.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:3.40.50.1870; UDP-Glc/GDP-Man_DH_C; 1.

PANTHER

PTHR11374; UDPG_MGDP_DH_Creg; 1.

Pfam

PF00984; UDPG_MGDP_dh; 1.
PF03720; UDPG_MGDP_dh_C; 1.
PF03721; UDPG_MGDP_dh_N; 1.
Pfam graphical view of domain structure.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase; Phosphoprotein.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 388`	`388`	`UDP-glucose 6-dehydrogenase.`	`PRO_0000074046`
`NP_BIND`	`2 19`	`18`	`NAD (Potential).`
`ACT_SITE`	`253 253`		`By similarity.`

Sequence information

Length: 388 AA [This is the length of the unprocessed precursor]

Molecular weight: 43549 Da [This is the MW of the unprocessed precursor]

CRC64: D30E622AA6489AC9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKITISGTGY VGLSNGILIA QNHEVVALDI VQAKVDMLNK KQSPIVDKEI EEYLATKDLN 

        70         80         90        100        110        120 
FRATTDKYDA YKNADYVIIA TPTDYDPKTN YFNTSSVEAV IRDVTEINPN AVMVIKSTIP 

       130        140        150        160        170        180 
VGFTKSIKER LGIDNLIFSP EFLREGKALY DNLHPSRIVI GERSERAERF AALLQEGAIK 

       190        200        210        220        230        240 
QNIPTLFTDS TEAEAIKLFA NTYLAMRVAY FNELDSYAES LGLNTRQIIE GVCLDPRIGN 

       250        260        270        280        290        300 
HYNNPSFGYG GYCLPKDTKQ LLANYQSVPN NLISAIVDAN RTRKDFIADA ILSRKPQVVG 

       310        320        330        340        350        360 
IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVMK EDSFFNSRLE RDLATFKQQA 

       370        380 
DVIISNRMAE ELKDVADKVY TRDLFGSD

O33952 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools