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UniProtKB/Swiss-Prot entry O29544


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTD_ARCFU
Primary accession number O29544
Secondary accession number Q9UWM0
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name F420-dependent methylenetetrahydromethanopterin dehydrogenase
Synonyms MTD
EC 1.5.99.9
Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase
Gene name
Name: mtd
OrderedLocusNames: AF_0714
From
Archaeoglobus fulgidus [TaxID: 2234] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
DOI=10.1038/37052; PubMed=9389475 [NCBI, ExPASy, EBI, Israel, Japan]
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.";
Nature 390:364-370(1997).
[2]
PROTEIN SEQUENCE OF 2-34, AND CHARACTERIZATION.
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
DOI=10.1007/BF00248476; PubMed=8481089 [NCBI, ExPASy, EBI, Israel, Japan]
Schworer B., Breitung J., Klein A.R., Stetter K.O., Thauer R.K.;
"Formylmethanofuran: tetrahydromethanopterin formyltransferase and N5,N10-methylenetetrahydromethanopterin dehydrogenase from the sulfate-reducing Archaeoglobus fulgidus: similarities with the enzymes from methanogenic Archaea.";
Arch. Microbiol. 159:225-232(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000782; AAB90526.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B69339; B69339.
RefSeq NP_069548.1; -.
3D structure databases
ModBase O29544.
Enzyme and pathway databases
BioCyc AFUL224325:AF_0714-MON; -.
Ontologies
GO
GO:0030268; Molecular function: methylenetetrahydromethanopterin dehydrogenase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00058; -; 1.
PBIL [Tree]
InterPro IPR002844; Methylene_DHase.
Graphical view of domain structure.
Pfam PF01993; MTD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF005627; MTD; 1.
BLOCKS O29544.
Genome annotation databases
GeneID 1483932; -.
GenomeReviews AE000782_GR; AF_0714.
KEGG afu:AF0714; -.
NMPDR fig|224325.1.peg.707; -.
TIGR AF_0714; -.
Phylogenomic databases
HOGENOM O29544; -.
Other
ProtoNet O29544.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; One-carbon metabolism; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   273  272     F420-dependent methylenetetrahydromethanopterin dehydrogenase. PRO_0000075036
Sequence information
Length: 273 AA [This is the length of the unprocessed precursor] Molecular weight: 29645 Da [This is the MW of the unprocessed precursor] CRC64: 335B2432D5FE7B7E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVVKVGVLKM GAIGTALLVE YLLDERADRE DIEVRVVTSG AKMQPEEAVV AEKLKEFDPD 

        70         80         90        100        110        120 
VVIVVSPNAA LPGPKAAREA FEGKPVIVIS DAPAKKAKDE LKEKGFGYIL INADSMIGAR 

       130        140        150        160        170        180 
REFLDPTEMA LFNADVVKVL AATGAFRLVQ EAIDKVIEDI KAGKQPELPQ IVVTAEKAVE 

       190        200        210        220        230        240 
AGKFSNPYAK AKAMAAFYIA EKVADIDVKG CFIEKDPEKY IPLVASAHEM MRIAAILADQ 

       250        260        270 
AREIEKSNDT VFRNPHAKDG KILGKTQLMA KPE 

O29544 in FASTA format

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