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UniProtKB/Swiss-Prot entry O27434

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HDRA_METTH
Primary accession number O27434
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on January 16, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 55)
Name and origin of the protein
Protein name CoB--CoM heterodisulfide reductase iron-sulfur subunit A
Synonym EC 1.8.98.1
Gene name
Name: hdrA
OrderedLocusNames: MTH_1381
From
Methanobacterium thermoautotrophicum [TaxID: 187420] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Delta H;
PubMed=9371463 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.";
J. Bacteriol. 179:7135-7155(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000666; AAB85858.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G69050; G69050.
RefSeq NP_276497.1; -.
3D structure databases
HSSP P07485; 1DWL. [HSSP ENTRY / PDB]
ModBase O27434.
Enzyme and pathway databases
BioCyc MTHE187420:MTH1381-MON; -.
Ontologies
GO
GO:0051912; Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR006076; FAD-dep_OxRdtase.
IPR001100; Pyr_nuc-diS_OxRdtase.
Graphical view of domain structure.
Pfam PF01266; DAO; 1.
PF00037; Fer4; 4.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00411; PNDRDTASEI.
PROSITE PS00198; 4FE4S_FER_1; 4.
PS51379; 4FE4S_FER_2; 4.
PROSITE graphical view of domain structure (profiles).
BLOCKS O27434.
Genome annotation databases
GeneID 1471098; -.
GenomeReviews AE000666_GR; MTH_1381.
KEGG mth:MTH1381; -.
NMPDR fig|187420.1.peg.1352; -.
Phylogenomic databases
HOGENOM O27434; -.
Other
LinkHub O27434; -.
Genome annotation databases
CMR O27434; MTH_1381.
Other
ProtoNet O27434.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   659  659     CoB--CoM heterodisulfide reductase iron-sulfur subunit A. PRO_0000150061
DOMAIN   245   275  31     4Fe-4S ferredoxin-type 1. 
DOMAIN   293   322  30     4Fe-4S ferredoxin-type 2. 
DOMAIN   582   611  30     4Fe-4S ferredoxin-type 3. 
DOMAIN   612   641  30     4Fe-4S ferredoxin-type 4. 
NP_BIND   159   182  24     FAD (Potential). 
METAL   255   255        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   258   258        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   261   261        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   265   265        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   302   302        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   305   305        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   308   308        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   312   312        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   592   592        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   595   595        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   598   598        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   602   602        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   621   621        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   624   624        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   627   627        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   631   631        Iron-sulfur 3 (4Fe-4S) (Potential). 
Sequence information
Length: 659 AA [This is the length of the unprocessed precursor] Molecular weight: 72392 Da [This is the MW of the unprocessed precursor] CRC64: ED517077EC5B6CBD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAEEKKEETM EEPRIGVYVC HCGVNIGGVV DIEAVRDYAA KLPNVVVSKD YKYYCSDPGQ 

        70         80         90        100        110        120 
LEIQKDIKEL GLNRVVVAAC SPRLHEPTFR RCVEEAGLNQ FLFEFANLRE QDSWVHMDDP 

       130        140        150        160        170        180 
EGATEKAKDL VRMAVAKARL LEPLEASKVS VDDKALVIGG GVAGIQTALD LADMGFKTYM 

       190        200        210        220        230        240 
VEKRPSISGR MGQLDKTFPT LDCSMCILAP KMVDVGKHDN IELITYAEVK EVDGYIGNFK 

       250        260        270        280        290        300 
VKIEKKPRYI DEDLCTGCGS CVEVCPIEMP NYFDEGIGMT KAVYIPFPQA VPLCATIDKD 

       310        320        330        340        350        360 
YCIECMLCDE ICERGAVKHD QEPEEIEIEV GTIIVATGYD AYDPTEKLEY GYGRHTNVIT 

       370        380        390        400        410        420 
GLELERMINA SGPTDGKVIK PSDGEKPKRV AFIHCVGSRD EQIGKPYCSR VCCMYIMKNA 

       430        440        450        460        470        480 
QLIKDKMPDT EVTLYYMDIR AFGKGFEEFY KRSQEKYGIK FIRGRPAEIL ENPDLTLTVR 

       490        500        510        520        530        540 
SEDTLLGKVT EYDYDMVVLG VGLVPPEGSE KLRQTIGLSK SADGFLMEAH PKLRPVDTLT 

       550        560        570        580        590        600 
DGVYLAGVAQ GPKDIPDAVA QASGAAARAA IPMVKGEVEI EPIVAVTDSD VCGGCEVCIE 

       610        620        630        640        650 
LCPFGAISIE EGHANVNVAL CKGCGTCVAA CPSGAMDQQH FRTEQIMAQI EAALNEQAK
O27434 in FASTA format

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