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UniProtKB/Swiss-Prot entry O27079

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CARA_METTH
Primary accession number O27079
Secondary accession numbers None
Integrated into Swiss-Prot on July 11, 2002
Sequence was last modified on July 11, 2002 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 65)
Name and origin of the protein
Protein name Carbamoyl-phosphate synthase small chain
Synonyms EC 6.3.5.5
Carbamoyl-phosphate synthetase glutamine chain
Gene name
Name: carA
OrderedLocusNames: MTH_998
From
Methanobacterium thermoautotrophicum [TaxID: 187420] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Delta H;
PubMed=9371463 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.";
J. Bacteriol. 179:7135-7155(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000666; AAB85495.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F69233; F69233.
RefSeq NP_276133.1; -.
3D structure databases
HSSP P00907; 1CS0. [HSSP ENTRY / PDB]
ModBase O27079.
Enzyme and pathway databases
BioCyc MTHE187420:MTH998-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004088; Molecular function: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (inferred from electronic annotation from HAMAP).
GO:0006526; Biological process: arginine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0006541; Biological process: glutamine metabolic process (inferred from electronic annotation from InterPro).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01209; -; 1.
PBIL [Tree]
InterPro IPR006220; Anth_synthII.
IPR001317; CarbamoylP_synth_GATase.
IPR006274; CarbamoylP_synth_ssu.
IPR002474; CarbamoylP_synth_ssu_N.
IPR011702; GATASE.
IPR012998; GATase_1_AS.
IPR000991; GATase_class1_C.
Graphical view of domain structure.
PANTHER PTHR11405:SF4; CarA_synth_small; 1.
Pfam PF00988; CPSase_sm_chain; 1.
PF00117; GATase; 1.
Pfam graphical view of domain structure.
PRINTS PR00097; ANTSNTHASEII.
PR00099; CPSGATASE.
PR00096; GATASE.
TIGRFAMs TIGR01368; CPSaseIIsmall; 1.
PROSITE PS51273; GATASE_TYPE_1; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet O27079.
Genome annotation databases
GeneID 1471406; -.
GenomeReviews AE000666_GR; MTH_998.
KEGG mth:MTH998; -.
NMPDR fig|187420.1.peg.988; -.
Phylogenomic databases
HOGENOM O27079; -.
Genome annotation databases
CMR O27079; MTH_998.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Glutamine amidotransferase; Ligase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   356  356     Carbamoyl-phosphate synthase small chain. PRO_0000112361
DOMAIN   176   356  181     Glutamine amidotransferase type-1. 
REGION   1   177  177     CPSase. 
ACT_SITE   251   251        Nucleophile (By similarity). 
ACT_SITE   336   336        By similarity. 
ACT_SITE   338   338        By similarity. 
Sequence information
Length: 356 AA [This is the length of the unprocessed precursor] Molecular weight: 38958 Da [This is the MW of the unprocessed precursor] CRC64: 2222F16A3429FFF7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFKEAKLALE DGTIIRGEAF GSETVKTGEV VFATGMTGYV ESLTDPSYRG QILMPTYPLQ 

        70         80         90        100        110        120 
GNYGVTEEWY QSDGIKAEGL IVREMCPAPS HSLSEKTLPE FLEEYGIPGI AGVDTRALTI 

       130        140        150        160        170        180 
KIRDKGTMKG ALATEEIDDD ELLEMAVKQP DITEIDLVDM VCVREPVILN EDASGRVVIV 

       190        200        210        220        230        240 
DCGIKRNSID ALLEKDLGVV IVPYTTSPAE IMDYEPDGLL ISSGPGDPTR VRDAIDTVKA 

       250        260        270        280        290        300 
LSERLPIFGI CLGQQIIALA FGARIYKMKF GHRGVNQPVK DLRSGTVSIT SQNHGFTVDP 

       310        320        330        340        350 
DSVKGTDIEI TQLNLNDGTP EGIEHRELPV FSVQYHPEAG PGPHDTVNIF DRLWMF
O27079 in FASTA format

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