ID   VORC_METTH              Reviewed;          79 AA.
AC   O26799;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   04-NOV-2008, entry version 54.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit vorC;
DE            Short=VOR;
DE            EC=1.2.7.7;
DE   AltName: Full=2-oxoisovalerate oxidoreductase gamma chain;
DE   AltName: Full=2-oxoisovalerate ferredoxin reductase subunit gamma;
GN   Name=vorC; OrderedLocusNames=MTH_703;
OS   Methanobacterium thermoautotrophicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized
CC       ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- COFACTOR: Binds 2 4Fe-4S clusters (By similarity).
CC   -!- SUBUNIT: Heterotrimer of the vorA, vorB and vorC subunits.
CC   -!- SIMILARITY: Contains 2 4Fe-4S ferredoxin-type domains.
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DR   EMBL; AE000666; AAB85208.1; -; Genomic_DNA.
DR   PIR; H69193; H69193.
DR   RefSeq; NP_275846.1; -.
DR   GeneID; 1470664; -.
DR   GenomeReviews; AE000666_GR; MTH_703.
DR   KEGG; mth:MTH703; -.
DR   NMPDR; fig|187420.1.peg.701; -.
DR   HOGENOM; O26799; -.
DR   BioCyc; MTHE187420:MTH703-MON; -.
DR   GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferr...; IEA:EC.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd.
DR   Pfam; PF00037; Fer4; 2.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur;
KW   Metal-binding; Oxidoreductase; Repeat; Transport.
FT   CHAIN         1     79       Ketoisovalerate oxidoreductase subunit
FT                                vorC.
FT                                /FTId=PRO_0000099959.
FT   DOMAIN        4     33       4Fe-4S ferredoxin-type 1.
FT   DOMAIN       40     70       4Fe-4S ferredoxin-type 2.
FT   METAL        13     13       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        16     16       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        19     19       Iron-sulfur 1 (4Fe-4S) (Potential).
FT   METAL        23     23       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        49     49       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        52     52       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        55     55       Iron-sulfur 2 (4Fe-4S) (Potential).
FT   METAL        59     59       Iron-sulfur 1 (4Fe-4S) (Potential).
SQ   SEQUENCE   79 AA;  8928 MW;  9DFE9CC6A2AE943E CRC64;
     MKKAYPVINS VECKACERCI IACPRKVLQM SSKINERGYH YVEYRGEGCN GCGNCYYTCP
     EINAIEVHIE RCEDGNTDG
//