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UniProtKB/Swiss-Prot entry O25525


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_HELPY
Primary accession number O25525
Secondary accession numbers None
Integrated into Swiss-Prot on March 15, 2004
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 50)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: HP_0854
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD07901.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F64626; F64626.
RefSeq NP_207648.1; -.
3D structure databases
HSSP P12268; 1B3O. [HSSP ENTRY / PDB]
SMR O25525; 5-321.
ModBase O25525.
Protein-protein interaction databases
DIP DIP:3407N; -.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS O25525.
Genome annotation databases
GeneID 899383; -.
GenomeReviews AE000511_GR; HP_0854.
KEGG hpy:HP0854; -.
NMPDR fig|85962.1.peg.845; -.
TIGR HP_0854; -.
Phylogenomic databases
HOGENOM O25525; -.
Other
ProtoNet O25525.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   327  327     GMP reductase. PRO_0000093756
NP_BIND   205   228  24     NADP (By similarity). 
ACT_SITE   176   176        Thioimidate intermediate (By similarity). 
Sequence information
Length: 327 AA [This is the length of the unprocessed precursor] Molecular weight: 36039 Da [This is the MW of the unprocessed precursor] CRC64: E9ED3053C3E103C8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLKVFDYED VQLIPNKCIV NSRSECDTTV ILGKHAFKMP IVPANMQTII NESIAEFLAE 

        70         80         90        100        110        120 
NGYFYIMHRF DGAARIPFVK KMKKRQWISS ISVGVKKEEC LFVEELAKQG LAPDYITIDI 

       130        140        150        160        170        180 
AHGHSNSVIE MIQRIKTHLP ETFVIAGNVG TPEAVRELEN AGADATKVGI GPGKVCITKI 

       190        200        210        220        230        240 
KTGFGTGGWQ LAALRWCAKA ARKPIIADGG IRTHGDIVKS IRFGATMVMI GSLFAGHEES 

       250        260        270        280        290        300 
SGETKIENGI AYKEYFGSAS EFQKGEKKNI EGKKIWIQHK GSLKDTLVEM HQDLQSSISY 

       310        320 
AGGRDLEAIR KVDYVIVKNS IFNGDAI 

O25525 in FASTA format

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