ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O25376

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name HEMN_HELPY
Primary accession number O25376
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name Oxygen-independent coproporphyrinogen III oxidase
Synonyms Coproporphyrinogenase
Coprogen oxidase
EC 1.3.99.22
Gene name
Name: hemN
OrderedLocusNames: HP_0665
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD07727.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A64603; A64603.
RefSeq NP_207459.1; -.
3D structure databases
ModBase O25376.
Ontologies
GO
GO:0051989; Molecular function: coproporphyrinogen dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR006638; Elp3/MiaB/NifB.
IPR004558; HemN.
IPR010723; HemN_C.
IPR007197; Radical_SAM.
Graphical view of domain structure.
Pfam PF06969; HemN_C; 1.
PF04055; Radical_SAM; 1.
Pfam graphical view of domain structure.
SMART SM00729; Elp3; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00538; hemN; 1.
BLOCKS O25376.
Genome annotation databases
GeneID 899306; -.
GenomeReviews AE000511_GR; HP_0665.
KEGG hpy:HP0665; -.
NMPDR fig|85962.1.peg.657; -.
TIGR HP_0665; -.
Phylogenomic databases
HOGENOM O25376; -.
Other
ProtoNet O25376.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Porphyrin biosynthesis; S-adenosyl-L-methionine.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   457  457     Oxygen-independent coproporphyrinogen III oxidase. PRO_0000109942
REGION   114   115  2     S-adenosyl-L-methionine 2 binding (By similarity). 
METAL   62    62        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
METAL   66    66        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
METAL   69    69        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
BINDING   56    56        S-adenosyl-L-methionine 1 (By similarity). 
BINDING   68    68        S-adenosyl-L-methionine 2; via carbonyl oxygen (By similarity). 
BINDING   113   113        S-adenosyl-L-methionine 1; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   147   147        S-adenosyl-L-methionine 1 (By similarity). 
BINDING   174   174        S-adenosyl-L-methionine 2 (By similarity). 
BINDING   186   186        S-adenosyl-L-methionine 2 (By similarity). 
BINDING   211   211        S-adenosyl-L-methionine 2 (By similarity). 
Sequence information
Length: 457 AA [This is the length of the unprocessed precursor] Molecular weight: 53246 Da [This is the MW of the unprocessed precursor] CRC64: 2578727AEFDE1218 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQTIDFEKFS QYSKPGPRYT SYPTAVEFNE NFNEESLKTA FFNHDNLKNP MPLSLYTHLP 

        70         80         90        100        110        120 
FCRSACYFCA CSVIYTSLEE KKIRYISYLK KELALLKNAM DTNREVAQFH YGGGTPTFFS 

       130        140        150        160        170        180 
PIQLDEITQS IQEVFPNFSK DIEMSCEIDP RHFTKEHMQT LFDRGFNRLS FGVQDFDFEV 

       190        200        210        220        230        240 
QKAIHRIQPF EMVQESVKLA RDYGIKSINF DLIYGLPNQT KEGFLKTLEW VLKLDPDRLA 

       250        260        270        280        290        300 
VFNYAHVPWV KKTMRKIDET LLPSLRDKLE ILESLISFLE KANYQMIGMD HFAKSDNELY 

       310        320        330        340        350        360 
LALQKAELRR NFQGYTTKKF TQTIGIGVTS IGEGGDYYTQ NYKDLHHYEK ALDLGHLPVE 

       370        380        390        400        410        420 
RGVALSQEDV LRKEVIMQMM SNLKLDYSKI EEKFSVDFKA HFKKELEKLK PYEEAGLLSF 

       430        440        450 
NSKGFEMTKT GGMLVRNMAM EFDAYLRGGE KHFSKTL
O25376 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by kr flag YPRC Korea Mirror sites: Australia Brazil Canada China Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!