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UniProtKB/Swiss-Prot entry O25011

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MSRAB_HELPY
Primary accession number O25011
Secondary accession number O85224
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Peptide methionine sulfoxide reductase msrA/msrB
Synonyms None
Includes Peptide methionine sulfoxide reductase msrA
     (Protein-methionine-S-oxide reductase)
     (EC 1.8.4.11)
     (Peptide-methionine (S)-S-oxide reductase)
     (Peptide Met(O) reductase)
Peptide methionine sulfoxide reductase msrB
     (EC 1.8.4.12)
     (Peptide-methionine (R)-S-oxide reductase)
Gene name
Name: msrAB
Synonyms: msrA
OrderedLocusNames: HP_0224
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 49503 / 60190;
PubMed=9596777 [NCBI, ExPASy, EBI, Israel, Japan]
Cao P., McClain M.S., Forsyth M.H., Cover T.L.;
"Extracellular release of antigenic proteins by Helicobacter pylori.";
Infect. Immun. 66:2984-2986(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD07291.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF053709; AAC24211.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H64547; H64547.
RefSeq NP_207022.1; -.
3D structure databases
HSSP P14930; 1L1D. [HSSP ENTRY / PDB]
ModBase O25011.
Protein-protein interaction databases
DIP DIP:3282N; -.
Ontologies
GO
GO:0033743; Molecular function: peptide-methionine (R)-S-oxide reductase activity (inferred from electronic annotation from EC).
GO:0008113; Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0006464; Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01400; fused; 1.
MF_01401; fused; 1.
PBIL [Tree]
InterPro IPR002569; MsrA.
IPR002579; MsrB.
Graphical view of domain structure.
Gene3D G3DSA:3.30.1060.10; MsrA; 1.
G3DSA:2.170.150.20; MsrB; 1.
Pfam PF01625; PMSR; 1.
PF01641; SelR; 1.
Pfam graphical view of domain structure.
ProDom PD004057; DUF25; 1.
PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00401; msrA; 1.
TIGR00357; MsrB; 1.
BLOCKS O25011.
Genome annotation databases
GeneID 900130; -.
GenomeReviews AE000511_GR; HP_0224.
KEGG hpy:HP0224; -.
NMPDR fig|85962.1.peg.220; -.
TIGR HP_0224; -.
Phylogenomic databases
HOGENOM O25011; -.
Other
ProtoNet O25011.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Multifunctional enzyme; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   359  359     Peptide methionine sulfoxide reductase msrA/msrB. PRO_0000138515
REGION   36   189  154     Peptide methionine sulfoxide reductase A. 
REGION   206   329  124     Peptide methionine sulfoxide reductase B. 
ACT_SITE   44    44        By similarity. 
ACT_SITE   318   318        By similarity. 
CONFLICT   9     9        N -> I (in Ref. 2; AAC24211). 
CONFLICT   15    15        A -> L (in Ref. 2; AAC24211). 
CONFLICT   23    23        S -> N (in Ref. 2; AAC24211). 
CONFLICT   135   135        A -> T (in Ref. 2; AAC24211). 
CONFLICT   142   142        H -> N (in Ref. 2; AAC24211). 
CONFLICT   170   170        E -> K (in Ref. 2; AAC24211). 
CONFLICT   181   181        S -> G (in Ref. 2; AAC24211). 
CONFLICT   198   198        D -> S (in Ref. 2; AAC24211). 
CONFLICT   346   346        K -> R (in Ref. 2; AAC24211). 
CONFLICT   354   354        N -> Q (in Ref. 2; AAC24211). 
CONFLICT   358   358        S -> T (in Ref. 2; AAC24211). 
Sequence information
Length: 359 AA [This is the length of the unprocessed precursor] Molecular weight: 41275 Da [This is the MW of the unprocessed precursor] CRC64: D481FAC5C60927B3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVLSYLKNF YLFLAIGAIM QASENMGSQH QKTDERVIYL AGGCFWGLEA YMERIYGVID 

        70         80         90        100        110        120 
ASSGYANGKT SSTNYEKLHE SDHAESVKVI YDPKKISLDK LLRYYFKVVD PVSVNKQGND 

       130        140        150        160        170        180 
VGRQYRTGIY YVNSADKEVI DHALKALQKE VKGKIAIEVE PLKNYVRAEE YHQDYLKKHP 

       190        200        210        220        230        240 
SGYCHIDLKK ADEVIVDDDK YTKPSDEVLK KKLTKLQYEV TQNKHTEKPF ENEYYNKEEE 

       250        260        270        280        290        300 
GIYVDITTGE PLFSSADKYD SGCGWPSFSK PINKDVVKYE DDESLNRKRI EVLSRIGKAH 

       310        320        330        340        350 
LGHVFNDGPK ELGGLRYCIN SAALRFIPLK DMEKEGYGEF IPYIKKGELK KYINDKKSH
O25011 in FASTA format

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