NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. King of Denmark;
PubMed=9301122 [NCBI, ExPASy, EBI, Israel, Japan]
Sugimoto M., Furui S., Suzuki Y.;
"Molecular cloning and characterization of a cDNA encoding putative phospholipid hydroperoxide glutathione peroxidase from spinach.";
Biosci. Biotechnol. Biochem. 61:1379-1381(1997).

Comments

FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (By similarity).
CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H₂O.
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the glutathione peroxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D63425; BAA22194.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

JC5619; JC5619.

3D structure databases

HSSP

P00435; 1GP1. [HSSP ENTRY / PDB]

ModBase

O23814.

Protein family/group databases

PeroxiBase

2925; SoGPx06.

Family and domain databases

InterPro

IPR000889; Glut_peroxidase.
IPR001452; SH3.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.30.10; Thioredoxin_fold; 1.

PANTHER

PTHR11592; Glut_peroxidase; 1.

Pfam

PF00255; GSHPx; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000303; Glutathion_perox; 1.

PRINTS

PR01011; GLUTPROXDASE.
PR00452; SH3DOMAIN.

PROSITE

PS00460; GLUTATHIONE_PEROXID_1; 1.
PS00763; GLUTATHIONE_PEROXID_2; 1.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 171`	`171`	`Probable phospholipid hydroperoxide glutathione peroxidase.`	`PRO_0000066635`
`ACT_SITE`	`44 44`		`By similarity.`

Sequence information

Length: 171 AA [This is the length of the unprocessed precursor]

Molecular weight: 19048 Da [This is the MW of the unprocessed precursor]

CRC64: 0DA82AAB80BAD476 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASDSSAQPK SVHEFVVRDA RGNDVDLSIY KGKVLLIVNV ASQCGLTNSN YTEMTELYEK 

        70         80         90        100        110        120 
YRELGLEILA FPCNQFGNQE PGSNEEVLEF ACTRFKAEYP IFDKVDVNGS NAAPIYKFLK 

       130        140        150        160        170 
SSKGGLFGDG LKWNFTKFLV DKDGNVVDRY APTTSPKSIE KDVKKLLGIQ K

O23814 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools