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UniProtKB/Swiss-Prot entry O19132

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NOS1_RABIT
Primary accession number O19132
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 81)
Name and origin of the protein
Protein name Nitric oxide synthase, brain
Synonyms EC 1.14.13.39
bNOS
NOS type I
Neuronal NOS
N-NOS
nNOS
Constitutive NOS
NC-NOS
Gene name
Name: NOS1
From
Oryctolagus cuniculus (Rabbit) [TaxID: 9986] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Jeong Y., Yim J.;
"Molecular cloning of a cDNA encoding a constitutive nitric oxide synthase from rabbit brain.";
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U91584; AAB68663.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001075854.1; -.
UniGene Ocu.2169
3D structure databases
HSSP P29476; 1OM4. [HSSP ENTRY / PDB]
SMR O19132; 12-126, 305-724, 969-1403.
ModBase O19132.
Family and domain databases
InterPro IPR003097; FAD-binding_1.
IPR001094; Flavdoxin_like.
IPR008254; Flavodoxin/NO_synth.
IPR001709; FPN_cyt_redctse.
IPR004030; NO_synthase_oxygenase_reg.
IPR012144; NOS.
IPR001433; OxRdtase_FAD/NAD_bd.
IPR001478; PDZ.
Graphical view of domain structure.
Gene3D G3DSA:3.90.340.10; NO_synthase_oxygenase_reg; 1.
Pfam PF00667; FAD_binding_1; 1.
PF00258; Flavodoxin_1; 1.
PF00175; NAD_binding_1; 1.
PF02898; NO_synthase; 1.
PF00595; PDZ; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000333; NOS; 1.
PRINTS PR00369; FLAVODOXIN.
PR00371; FPNCR.
SMART SM00228; PDZ; 1.
SMART graphical view of domain structure.
PROSITE PS51384; FAD_FR; 1.
PS50902; FLAVODOXIN_LIKE; 1.
PS60001; NOS; 1.
PS50106; PDZ; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O19132.
Genome annotation databases
GeneID 100009243; -.
Phylogenomic databases
HOVERGEN O19132; -.
Other
ProtoNet O19132.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calmodulin-binding; Cell membrane; Cell projection; FAD; FMN; Heme; Iron; Membrane; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1435  1435     Nitric oxide synthase, brain. PRO_0000170923
DOMAIN   17     99  83     PDZ. 
DOMAIN   761    941  181     Flavodoxin-like. 
DOMAIN   996   1243  248     FAD-binding FR-type. 
NP_BIND   887    918  32     FMN (By similarity). 
NP_BIND   1033   1044  12     FAD (By similarity). 
NP_BIND   1176   1186  11     FAD (By similarity). 
NP_BIND   1251   1269  19     NADP (By similarity). 
NP_BIND   1349   1364  16     NADP (By similarity). 
REGION   1    206  206     Interaction with NOSIP (By similarity). 
REGION   164    246  83     PIN (nNOS-inhibiting protein) binding (By similarity). 
REGION   731    751  21     Calmodulin-binding (Potential). 
REGION   756    775  20     Tetrahydrobiopterin-binding (By similarity). 
METAL   421    421        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 1435 AA [This is the length of the unprocessed precursor] Molecular weight: 160865 Da [This is the MW of the unprocessed precursor] CRC64: 3ED87ECDD83A7A5A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEEHVFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG AAEQSGLIQA 

        70         80         90        100        110        120 
GDIILAVNGR PLVDLSYDSA LEVLRGVASE THVVLILRGP EGFTTNLETT FTGDGTPKTI 

       130        140        150        160        170        180 
RVTQPLGAPT KAVDLSHQPP SAGKEQPRPV DGAAGPGSWP QPTQGHGQEA GSPSRANGLA 

       190        200        210        220        230        240 
PRTSSQDPAK KSGWAGLQGS GDKNELLKEI EPVLTLLAGG SKAVDGGGPA KAETRDTGVQ 

       250        260        270        280        290        300 
VDRDFDAKSH KPLPLGVEND RVFSDLWGKG SAPVVLNNPY SEKEQPPASG KQSPTKNGSP 

       310        320        330        340        350        360 
SKCPRFLKVK NWETDVVLTD TLHLKSTLET GCTEHICMGS IMFPSQHTRR PEDIRTKEQL 

       370        380        390        400        410        420 
FPLAKEFIDQ YYSSIKRFGS KAHMERLEEV NKEIESTSTY QLKDTELIYG AKHAWRNASR 

       430        440        450        460        470        480 
CVGRIQWSKL QVFDARDCTT AHGMFNYICN HIKYATNKGN LRSAITIFPQ RTDGKHDFRV 

       490        500        510        520        530        540 
WNSQLIRYAG YKQPDGSTLG DPANVQFTEI CIQQGWKPPR SRFDVLPLLL QANGNDPELF 

       550        560        570        580        590        600 
QIPPELVLEV PIRHPKFEWF KDLGLKWYGL PAVSNMLLEI GGLEFSACPF SGWYMGTEIG 

       610        620        630        640        650        660 
VRDYCDNSRY NILEEVAKKM NLDMRKTSSL WKDQALVEIN IAVLYSFQSD KVTIVDHHSA 

       670        680        690        700        710        720 
TESFIKHMEN EYRCRGGCPA DWVWIVPPMS GSITPVFHQE MLNYRLTPCF EYQPDPWNTH 

       730        740        750        760        770        780 
VWKGTNGTPT KRRAIGFKKL AEAVKFSAKL MGQAMAKRVK ATILYATETG KSQAYAKTLC 

       790        800        810        820        830        840 
EIFKHAFDAK VMSMEEYDIV HLEHETLVLV VTSTFGNGDP PENGEKFRCA LMEMRHPNSL 

       850        860        870        880        890        900 
QEERKSYKVR FNSVSSYSDS RKSSGDGPDV RDHFESAGPL ANVRFSVFGL GSRAYPHFCA 

       910        920        930        940        950        960 
FGHAVDTLLE ELGGERILKM REGDELCGQE EAFRTWAKKV FKAACDVFCV GDDVNIEKAN 

       970        980        990       1000       1010       1020 
NSLISNDRSW KRNKFRLTYV AEAPGLTQGL SSVHKKRVSA ARLLSRQNLQ SPKSSRSTIF 

      1030       1040       1050       1060       1070       1080 
VRLHTNGSQE LQYQPGDHLG VFPGNHEDLV NALIERLEDA PPANQMVKVE LLEERNTALG 

      1090       1100       1110       1120       1130       1140 
VISNWKDEPR LPPCTVFQAF KYYLDITTPP TPLQLQQFAS LASNEKEKQR LLVLSKGLQE 

      1150       1160       1170       1180       1190       1200 
YEEWKWGKNP TIVEVLEEFP SIQMPATLLL TQLSLLQPRY YSISSSPDMY PDEVHLTVAI 

      1210       1220       1230       1240       1250       1260 
VSYHTRDGEG PIHHGVCSSW LNRIPADEVV PCFVRGAPSF RLPRNPQVPC ILVGPGTAFA 

      1270       1280       1290       1300       1310       1320 
PFRSFWQQRQ FDIQHKGMSP CPMVLVFGCR QSKIDHIYRE EALQAKNKGV FRELYTAYSR 

      1330       1340       1350       1360       1370       1380 
EPDKPKKYVQ DILQEQLAEQ VYRALKEQGG HIYVCGDVTM AADVLKAVQR IMAQQGKLSA 

      1390       1400       1410       1420       1430 
EDAGVFISRL RDDNRYHEDI FGVTLRTYEV TNRLRSESIA FIEESKKDTD EVFSS
O19132 in FASTA format

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