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UniProtKB/Swiss-Prot entry O19043

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LOX12_RABIT
Primary accession number O19043
Secondary accession numbers None
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 56)
Name and origin of the protein
Protein name Arachidonate 12-lipoxygenase, 12S-type
Synonyms 12-LOX
EC 1.13.11.31
Gene name
Name: ALOX12
From
Oryctolagus cuniculus (Rabbit) [TaxID: 9986] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
DOI=10.1006/jmbi.1998.1737; PubMed=9600854 [NCBI, ExPASy, EBI, Israel, Japan]
Berger M., Schwarz K., Thiele H., Reimann I., Huth A., Borngraeber S., Kuehn H., Thiele B.-J.;
"Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits.";
J. Mol. Biol. 278:935-948(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z97654; CAB10746.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P12530; 1LOX. [HSSP ENTRY / PDB]
SMR O19043; 2-663.
ModBase O19043.
Family and domain databases
InterPro IPR000907; LipOase.
IPR013819; LipOase_C.
IPR001024; LipOase_LH2.
IPR001885; LipOase_mml.
Graphical view of domain structure.
Gene3D G3DSA:2.60.60.20; Lipase_LipOase; 1.
PANTHER PTHR11771; LipOase; 1.
Pfam PF00305; Lipoxygenase; 1.
PF01477; PLAT; 1.
Pfam graphical view of domain structure.
PRINTS PR00087; LIPOXYGENASE.
PR00467; MAMLPOXGNASE.
SMART SM00308; LH2; 1.
SMART graphical view of domain structure.
PROSITE PS00711; LIPOXYGENASE_1; 1.
PS00081; LIPOXYGENASE_2; 1.
PS51393; LIPOXYGENASE_3; 1.
PS50095; PLAT; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O19043.
Phylogenomic databases
HOVERGEN O19043; -.
Other
ProtoNet O19043.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Metal-binding; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   663  662     Arachidonate 12-lipoxygenase, 12S-type. PRO_0000220685
DOMAIN   2   115  114     PLAT. 
DOMAIN   116   663  548     Lipoxygenase. 
METAL   361   361        Iron; catalytic (By similarity). 
METAL   366   366        Iron; catalytic (By similarity). 
METAL   541   541        Iron; catalytic (By similarity). 
METAL   663   663        Iron; via carboxylate; catalytic (By similarity). 
Sequence information
Length: 663 AA [This is the length of the unprocessed precursor] Molecular weight: 75234 Da [This is the MW of the unprocessed precursor] CRC64: 19670402E5C22A8B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGVYRVCVST GASIYAGSKN KVELWLVGQH GEVELGSCLR PSRNKEEEFK VNVSKYLGSL 

        70         80         90        100        110        120 
LFVKLRKKHF LKEDAWFCNW ISVQALGAAE DKYWFPCYRW VVGDGVQSLP VGTGCTTVGD 

       130        140        150        160        170        180 
PQGLFQKHRE QELEERRKLY QWGSWKEGLI LNVAGSKLTD LPVDERFLED KKIDFEASLA 

       190        200        210        220        230        240 
WGLAELALKN SLNILAPWKT LDDFNRIFWC GRSKLARRVR DSWQEDSLFG YQFLNGANPM 

       250        260        270        280        290        300 
LLRRSVQLPA RLVFPPGMEE LQAQLEKELK AGTLFEADFA LLDNIKANVI LYCQQYLAAP 

       310        320        330        340        350        360 
LVMLKLQPDG KLMPMVIQLH LPKIGSSPPP LFLPTDPPMV WLLAKCWVRS SDLQVHELNS 

       370        380        390        400        410        420 
HLLRGHLMAE VFTVATMRCL PSIHPVFKLI VPHLRYTLEI NVRARNGLVS DFGIFDQIMS 

       430        440        450        460        470        480 
TGGGGHVQLL QQAGAFLTYR SFCPPDDLAD RGLLGVESSF YAQDALRLWE IISRYVQGIM 

       490        500        510        520        530        540 
GLYYKTDEAV RDDLELQSWC REITEIGLQG AQKQGFPTSL QSVAQACHFV TMCIFTCTGQ 

       550        560        570        580        590        600 
HSSIHLGQLD WFTWVPNAPC TMRLPPPTTK DATLETVMAT LPNLHQSSLQ MSIVWQLGRD 

       610        620        630        640        650        660 
QPIMVPLGQH QEEYFSGPEP RAVLEKFREE LAIMDKEIEV RNEKLDIPYE YLRPSIVENS 


VAI
O19043 in FASTA format

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