[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Puerto Rican; PubMed=9751167 [NCBI, ExPASy, EBI, Israel, Japan] Hamdan F.F., Ribeiro P.; "Cloning and characterization of a novel form of tyrosine hydroxylase from the human parasite, Schistosoma mansoni."; J. Neurochem. 71:1369-1380(1998).

Comments

CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O₂ = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.
COFACTOR: Fe(2+) ion.
PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2 .
SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF030336; AAC62256.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P04177; 1TOH. [HSSP ENTRY / PDB]

ModBase

O17446.

Family and domain databases

InterPro

IPR001273; Aaa_hydroxylase.
IPR005962; Tyr_3_mOase.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.800.10; Aaa_hydroxylase; 1.

PANTHER

PTHR11473; Aaa_hydroxylase; 1.

Pfam

PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.

PRINTS

PR00372; FYWHYDRXLASE.

ProDom

PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01269; Tyr_3_monoox; 1.

PROSITE

PS00367; BIOPTERIN_HYDROXYL; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Catecholamine biosynthesis; Iron; Metal-binding; Monooxygenase; Neurotransmitter biosynthesis; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 465`	`465`	`Tyrosine 3-monooxygenase.`	`PRO_0000205567`
`METAL`	`294 294`		`Iron (By similarity).`
`METAL`	`299 299`		`Iron (By similarity).`
`METAL`	`339 339`		`Iron (By similarity).`

Sequence information

Length: 465 AA [This is the length of the unprocessed precursor]

Molecular weight: 54081 Da [This is the MW of the unprocessed precursor]

CRC64: 0DE47B4A474665CB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKMTMMCDES IEENNKSSTV ELNHNEKDGR IHSIIINFHP ITHEQSNNQF YIQTLHEILK 

        70         80         90        100        110        120 
YIIDKKLNLV HFETRPTLTL SNANRDVQYS CLITLEANEI NMSLLYEELR GNSFISGINL 

       130        140        150        160        170        180 
LNNQESEDWY PKHISDLDKC QHLLRKFQPE LQTDHPGFHD KVYRERREAI AKIAFQYKYG 

       190        200        210        220        230        240 
DRIPEVEYTK EEIETWGLVF TKMKAVHASR ACREYIDGFQ LLEKYCNYNS ESIPQLQTIC 

       250        260        270        280        290        300 
EFMHRTSGFR IRPVAGLVSP KDFLASLAFR VFQCTQYIRH HSRPMHTPEP DCIHELIGHM 

       310        320        330        340        350        360 
PMLVNRQFAD FSQELGLASL GASEEEITRL STLYWFTVEF GLCNENGETR ALGAGIMSSY 

       370        380        390        400        410        420 
GELENAFSDL SVKEPFNIND AAVQVYDDVG YQKIYFVTES IESMKRELRN YINTSGKSTI 

       430        440        450        460 
PIYDPITETV HMKSRFSIRK ELLKHVKEEI GQLDTLLNHS NYTLP

O17446 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools