[1]	NUCLEOTIDE SEQUENCE [MRNA]. McGonigle S., James E.R.; "1-Cys peroxidoxin from Dirofilaria immitis."; Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Thiol specific antioxidant.
CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: Cys-49 is the site of oxidation by H(2)O(2). The oxidized intermediate might be Cys-SOH (By similarity).
SIMILARITY: Belongs to the ahpC/TSA family. Rehydrin subfamily.
SIMILARITY: Contains 1 thioredoxin domain.

Copyright

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Cross-references

Sequence databases

EMBL

AF027387; AAB83998.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P30041; 1PRX. [HSSP ENTRY / PDB]

ModBase

O17433.

Protein family/group databases

PeroxiBase

4935; Di1CysPrx.

Ontologies

GO:0051920;	Molecular function: peroxiredoxin activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR000866; AhpC-TSA.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.30.10; Thioredoxin_fold; 1.

Pfam

PF00578; AhpC-TSA; 1.
Pfam graphical view of domain structure.

PROSITE

PS51352; THIOREDOXIN_2; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antioxidant; Cytoplasm; Oxidoreductase; Peroxidase; Redox-active center.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 235`	`235`	`1-Cys peroxiredoxin.`	`PRO_0000135106`
`DOMAIN`	`5 179`	`175`	`Thioredoxin.`
`ACT_SITE`	`49 49`		`By similarity.`

Sequence information

Length: 235 AA [This is the length of the unprocessed precursor]

Molecular weight: 26342 Da [This is the MW of the unprocessed precursor]

CRC64: BCC198C87D88FD97 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTKGILLGDK FPDFRAETNE GFIPSFYDWI GKDSWAILFS HPRDFTPVCT TELARLVQLA 

        70         80         90        100        110        120 
PEFNKRNVKL IGLSCDSAES HRKWVDDIMA VCKMKCNDGD TCCSGNKLPF PIIADENRFL 

       130        140        150        160        170        180 
ATELGMMDPD ERDENGNALT ARCVFIIGPE KTLKLSILYP ATTGRNFDEI LRVVDSLQLT 

       190        200        210        220        230 
AVKLVATPVD WKDGDDCVVL PTIDDTEAKK LFGEKINTIE LPSGKHYLRM VAHPK

O17433 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools