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UniProtKB/Swiss-Prot entry O15156


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ZBT7B_HUMAN
Primary accession number O15156
Secondary accession numbers Q68DR2 Q96EP2
Integrated into Swiss-Prot on August 16, 2004
Sequence was last modified on August 16, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Zinc finger and BTB domain-containing protein 7B
Synonyms Zinc finger protein 67 homolog
Zfp-67
Zinc finger and BTB domain-containing protein 15
Zinc finger protein Th-POK
T-helper-inducing POZ/Krueppel-like factor
Krueppel-related zinc finger protein cKrox
hcKrox
Gene name
Name: ZBTB7B
Synonyms: ZBTB15, ZFP67
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
TISSUE=Skin fibroblast;
DOI=10.1016/S0378-1119(97)00360-0; PubMed=9370309 [NCBI, ExPASy, EBI, Israel, Japan]
Widom R.L., Culic I., Lee J.Y., Korn J.H.;
"Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression.";
Gene 198:407-420(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Salivary gland;
The German cDNA consortium;
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
  • FUNCTION: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
  • SUBCELLULAR LOCATION: Nucleus.
  • SIMILARITY: Contains 1 BTB (POZ) domain.
  • SIMILARITY: Contains 4 C2H2-type zinc fingers.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF007833; AAC51847.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR749303; CAH18158.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL451085; CAI13266.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012070; AAH12070.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_056956.2; -.
UniGene Hs.505855
3D structure databases
HSSP P08047; 1SP2. [HSSP ENTRY / PDB]
ModBase O15156.
Organism-specific databases
HGNC HGNC:18668; ZBTB7B.
GenAtlas ZBTB7B.
MIM 607646; gene. [NCBI / EBI]
PharmGKB PA38630; -.
GeneCards O15156.
Gene expression databases
ArrayExpress O15156; -.
CleanEx HS_ZBTB7B; -.
GermOnline ENSG00000160685; Homo sapiens.
Ontologies
GO
GO:0003704; Molecular function: specific RNA polymerase II transcription factor activity (traceable author statement from ProtInc).
GO:0007398; Biological process: ectoderm development (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000210; BTB/POZ-like.
IPR011333; BTB/POZ_fold.
IPR013069; BTB_POZ.
IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.710.10; BTB/POZ_fold; 1.
G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 2.
Pfam PF00651; BTB; 1.
PF00096; zf-C2H2; 3.
Pfam graphical view of domain structure.
SMART SM00225; BTB; 1.
SM00355; ZnF_C2H2; 4.
SMART graphical view of domain structure.
PROSITE PS50097; BTB; 1.
PS00028; ZINC_FINGER_C2H2_1; 3.
PS50157; ZINC_FINGER_C2H2_2; 4.
PROSITE graphical view of domain structure (profiles).
BLOCKS O15156.
Genome annotation databases
Ensembl ENSG00000160685; Homo sapiens. [Contig view]
GeneID 51043; -.
KEGG hsa:51043; -.
Phylogenomic databases
HOGENOM O15156; -.
HOVERGEN O15156; -.
Other
SOURCE ZBTB7B; Homo sapiens.
ProtoNet O15156.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Developmental protein; Differentiation; DNA-binding; Metal-binding; Nucleus; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   539  539     Zinc finger and BTB domain-containing protein 7B. PRO_0000047719
DOMAIN   34   115  82     BTB. 
ZN_FING   346   368  23     C2H2-type 1. 
ZN_FING   374   396  23     C2H2-type 2. 
ZN_FING   402   424  23     C2H2-type 3. 
ZN_FING   430   454  25     C2H2-type 4; atypical. 
COMPBIAS   181   196  16     Pro-rich. 
CONFLICT   437   437        K -> R (in Ref. 1; AAC51847). 
CONFLICT   480   480        S -> F (in Ref. 1; AAC51847). 
CONFLICT   509   510        GP -> WA (in Ref. 1; AAC51847). 
Sequence information
Length: 539 AA [This is the length of the unprocessed precursor] Molecular weight: 58027 Da [This is the MW of the unprocessed precursor] CRC64: 86B3616504B05B7E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK 

        70         80         90        100        110        120 
KLFTEGGGGA VMGAGGSGTA TGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA 

       130        140        150        160        170        180 
VLQAARLLEI PCVIAACMEI LQGSGLEAPS PDEDDCERAR QYLEAFATAT ASGVPNGEDS 

       190        200        210        220        230        240 
PPQVPLPPPP PPPPRPVARR SRKPRKAFLQ TKGARANHLV PEVPTVPAHP LTYEEEEVAG 

       250        260        270        280        290        300 
RVGSSGGSGP GDSYSPPTGT ASPPEGPQSY EPYEGEEEEE ELVYPPAYGL AQGGGPPLSP 

       310        320        330        340        350        360 
EELGSDEDAI DPDLMAYLSS LHQDNLAPGL DSQDKLVRKR RSQMPQECPV CHKIIHGAGK 

       370        380        390        400        410        420 
LPRHMRTHTG EKPFACEVCG VRFTRNDKLK IHMRKHTGER PYSCPHCPAR FLHSYDLKNH 

       430        440        450        460        470        480 
MHLHTGDRPY ECHLCHKAFA KEDHLQRHLK GQNCLEVRTR RRRKDDAPPH YPPPSTAAAS 

       490        500        510        520        530 
PAGLDLSNGH LDTFRLSLAR FWEQSAPTGP PVSTPGPPDD DEEEGAPTTP QAEGAMESS 

O15156 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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