[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 10259 / CBS 5796 / IFO 1060 / JCM 2078; Watanabe M., Ishii N., Arisawa M., Aoki Y.; Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP⁺ = D-ribulose 5-phosphate + CO₂ + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 .
SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.

Copyright

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Cross-references

Sequence databases

EMBL

AB006102; BAA21690.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00349; 2PGD. [HSSP ENTRY / PDB]

ModBase

O13287.

Family and domain databases

InterPro

IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

Pfam

PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.

PRINTS

PR00076; 6PGDHDRGNASE.

TIGR00873; gnd; 1.

PS00461; 6PGD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NADP; Oxidoreductase; Pentose shunt.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 517`	`517`		`6-phosphogluconate dehydrogenase, decarboxylating.`	`PRO_0000090072`

Sequence information

Length: 517 AA [This is the length of the unprocessed precursor]

Molecular weight: 56924 Da [This is the MW of the unprocessed precursor]

CRC64: 91E3F520FFCABF7A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKNFNALSRL SILSKQLSFN NTNSSIARGD IGLIGLAVMG QNLILNMADH GYTVVAYNRT 

        70         80         90        100        110        120 
TAKVDRFLEN EAKGKSILGA HSIKELVDQL KRPRRIMLLV KAGAPVDEFI NQLLPYLEEG 

       130        140        150        160        170        180 
DIIIDGGNSH FPDSNRRYEE LAKKGILFVG SGVSGGEEGA RTGPSLMPGG NEKAWPHIKE 

       190        200        210        220        230        240 
IFQDVAAKSD GEPCCDWVGD AGAGHYVKMV HNGIEYGDMQ LICEAYDLMK RVGKFEDKEI 

       250        260        270        280        290        300 
GDVFATWNKG VLDSFLIEIT RDILYYNDPT DGKPLVEKIL DTAGQKGTGK WTAVNALDLG 

       310        320        330        340        350        360 
IPVTLIGEAV FSRCLSAMKA ERVEASKALK GPQVTGESPI TDKKQFIDDL EQALYASKII 

       370        380        390        400        410        420 
SYTQGFMLMN QAAKDYGWKL NNAGIALMWR GGCIIRSVFL AEITAAYRKK PDLENLLLYP 

       430        440        450        460        470        480 
FFNDAITKAQ SGWRASVGKA IQYGIPTPAF STALAFYDGL RSERLPANLL QAQRDYFGAH 

       490        500        510 
TFKVLPGQEN ELLKKDEWIH INWTGRGGDV SSTTYDA

O13287 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools