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UniProtKB/Swiss-Prot entry O05269


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_BACSU
Primary accession number O05269
Secondary accession numbers None
Integrated into Swiss-Prot on March 15, 2004
Sequence was last modified on July 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
Synonyms: yumD
OrderedLocusNames: BSU32130
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
Oudega B., Koningstein G., de Sales Ramon M., Rodrigues L.;
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
[3]
PROBABLE FUNCTION, AND REGULATION OF EXPRESSION.
STRAIN=168;
DOI=10.1128/JB.183.21.6175-6183.2001; PubMed=11591660 [NCBI, ExPASy, EBI, Israel, Japan]
Saxild H.H., Brunstedt K., Nielsen K.I., Jarmer H., Nygaard P.;
"Definition of the Bacillus subtilis PurR operator using genetic and bioinformatic tools and expansion of the PurR regulon with glyA, guaC, pbuG, xpt-pbuX, yqhZ-folD, and pbuO.";
J. Bacteriol. 183:6175-6183(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z93939; CAB07955.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99120; CAB15203.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C70015; C70015.
RefSeq NP_391093.1; -.
3D structure databases
HSSP P12268; 1B3O. [HSSP ENTRY / PDB]
SMR O05269; 1-321.
ModBase O05269.
Enzyme and pathway databases
BioCyc BSUB224308:BSU3210-MON; -.
Organism-specific databases
SubtiList BG12392; guaC. [Micado]
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS O05269.
Genome annotation databases
GeneID 937189; -.
GenomeReviews AL009126_GR; BSU32130.
KEGG bsu:BSU32130; -.
NMPDR fig|224308.1.peg.3219; -.
Phylogenomic databases
HOGENOM O05269; -.
Genome annotation databases
CMR O05269; BSU32130.
Other
ProtoNet O05269.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   326  326     GMP reductase. PRO_0000093752
NP_BIND   204   227  24     NADP (By similarity). 
ACT_SITE   175   175        Thioimidate intermediate (By similarity). 
Sequence information
Length: 326 AA [This is the length of the unprocessed precursor] Molecular weight: 35819 Da [This is the MW of the unprocessed precursor] CRC64: 4D5EC6F22951D353 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MENVFDYEDI QLIPAKCIVN SRSECDTSVR LGGHTFKLPV VPANMQTIID EKLAISLAEN 

        70         80         90        100        110        120 
GYFYVMHRFE PETRIDFIKD MNARGLFSSI SVGVKDEEYE FVRQLAEENL TPEYVTIDIA 

       130        140        150        160        170        180 
HGHSNAVIEM IQHLKKHLPD SFVIAGNVGT PEAVRELENA GADATKVGIG PGKVCITKIK 

       190        200        210        220        230        240 
TGFGTGGWQL AALRWCAKAA SKPIIADGGI RTHGDIAKSI RFGATMVMIG SLFAGHEESP 

       250        260        270        280        290        300 
GQTIEKDGKL YKEYFGSASE FPKGEKKNVE GKKMHVAHKG SIKDTLIEME QDLQSSISYA 

       310        320 
GGTKLNAIRN VDYVIVKNSI FNGDKY 

O05269 in FASTA format

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