[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Leaf; PubMed=10353219 [NCBI, ExPASy, EBI, Israel, Japan] Ficarelli A., Tassi F., Restivo F.M.; "Isolation and characterization of two cDNA clones encoding for glutamate dehydrogenase in Nicotiana plumbaginifolia."; Plant Cell Physiol. 40:339-342(1999).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. TISSUE=Leaf; Restivo F.M., Panizzi N., De Monte G., Ficarelli A.; "Genomic organisation of GDH genes in Nicotiana plumbaginifolia."; Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-glutamate + H₂O + NAD(P)⁺ = 2-oxoglutarate + NH₃ + NAD(P)H.
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Y08292; CAA69600.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ277949; CAB94836.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T16981; T16981.

3D structure databases

HSSP

P96110; 1B26. [HSSP ENTRY / PDB]

ModBase

O04937.

Ontologies

GO:0004353;	Molecular function: glutamate dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11606:SF2; GLFV_DH; 1.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000185; Glu_DH; 1.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; FALSE_NEG.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 411`	`411`	`Glutamate dehydrogenase A.`	`PRO_0000182750`
`ACT_SITE`	`102 102`		`By similarity.`

Sequence information

Length: 411 AA [This is the length of the unprocessed precursor]

Molecular weight: 44796 Da [This is the MW of the unprocessed precursor]

CRC64: 5CCF132AF2103904 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNALAATNRN FRQAARILGL DSKLEKSLLI PFREIKVECT IPKDDGTLVS YVGFRVQHDN 

        70         80         90        100        110        120 
ARGPMKGGIR YHPEVDLDEV NALAQLMTWK TAVADIPYGG AKGGIGCKPK DLSKSELERL 

       130        140        150        160        170        180 
TRVFTQKIHD LIGINTDVPA PDMGTNAQTM AWILDEYSKF HGHSPAIVTG KPIDLGGSLG 

       190        200        210        220        230        240 
REAATGRGVV YATEALLAEY GKNIKDLTFA IQGFGNVGAW AAKLIHERGG KVIAVSDITG 

       250        260        270        280        290        300 
AVKNPNGLDI PALLNHKEAT GKLIDFSGGD VMNSDEVLTH ECDVLIPCAL GGVLNRENAD 

       310        320        330        340        350        360 
NVKAKFIIEA ANHPTDPEAD EILCKKGIVI LPDIYANAGG VTVSYFEWVQ NIQGFMWDEE 

       370        380        390        400        410 
KVNRELRKYM TKAFHNLKNM CQSHNCSLRM GAFTLGVNRV ARATTLRGWE A

O04937 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools