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UniProtKB/Swiss-Prot entry O00097

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_PICST
Primary accession number O00097
Secondary accession number A3LNN7
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on July 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms EC 1.1.1.1
Alcohol dehydrogenase I
ADH 2
Gene name
Name: ADH1
Synonyms: ADH2
ORFNames: PICST_68558
From
Pichia stipitis (Yeast) [TaxID: 4924] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Pichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 58785 / CBS 6054 / IFO 10063 / NRRL Y-11545;
PubMed=9546172 [NCBI, ExPASy, EBI, Israel, Japan]
Cho J.Y., Jeffries T.W.;
"Pichia stipitis genes for alcohol dehydrogenase with fermentative and respiratory functions.";
Appl. Environ. Microbiol. 64:1350-1358(1998).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 62970 / CBS 5774 / NRRL Y-11542;
DOI=10.1002/(SICI)1097-0061(1998100)14:14<1311::AID-YEA315>3.3.CO;2-K; PubMed=9802210 [NCBI, ExPASy, EBI, Israel, Japan]
Passoth V., Schaefer B., Liebel B., Weierstall T., Klinner U.;
"Molecular cloning of alcohol dehydrogenase genes of the yeast Pichia stipitis and identification of the fermentative ADH.";
Yeast 14:1311-1325(1998).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 58785 / CBS 6054 / IFO 10063 / NRRL Y-11545;
DOI=10.1038/nbt1290; PubMed=17334359 [NCBI, ExPASy, EBI, Israel, Japan]
Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S., Passoth V., Richardson P.M.;
"Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis.";
Nat. Biotechnol. 25:319-326(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF008245; AAC49991.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y13397; CAA73827.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000496; ABN64893.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001382922.1; -.
3D structure databases
HSSP P39462; 1JVB. [HSSP ENTRY / PDB]
SMR O00097; 2-348.
ModBase O00097.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS O00097.
Genome annotation databases
GeneID 4836752; -.
KEGG pic:PICST_68558; -.
Other
ProtoNet O00097.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   348  348     Alcohol dehydrogenase 1. PRO_0000160727
METAL   44    44        Zinc 1 (catalytic) (By similarity). 
METAL   67    67        Zinc 1 (catalytic) (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   154   154        Zinc 1 (catalytic) (By similarity). 
Sequence information
Length: 348 AA [This is the length of the unprocessed precursor] Molecular weight: 36520 Da [This is the MW of the unprocessed precursor] CRC64: 49C06B545D5350F4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSVPTTQKAV VFESNGGPLL YKDIPVPTPK PNEILINVKY SGVCHTDLHA WKGDWPLDTK 

        70         80         90        100        110        120 
LPLVGGHEGA GVVVGIGSNV TGWELGDYAG IKWLNGSCLN CEFCQHSDEP NCAKADLSGY 

       130        140        150        160        170        180 
THDGSFQQYA TADAVQAARL PKGTDLAQAA PILCAGITVY KALKTAQIQP GNWVCISGAG 

       190        200        210        220        230        240 
GGLGSLAIQY AKAMGFRVIA IDGGEEKGEF VKSLGAEAYV DFTVSKDIVK DIQTATDGGP 

       250        260        270        280        290        300 
HAAINVSVSE KAIAQSCQYV RSTGTVVLVG LPAGAKVVAP VFDAVVKSIS IRGSYVGNRA 

       310        320        330        340 
DSAEAIDFFT RGLIKCPIKV VGLSELPKVY ELMEAGKVIG RYVVDTSK
O00097 in FASTA format

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