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UniProtKB/Swiss-Prot entry O00091


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_SCHPO
Primary accession number O00091
Secondary accession number Q9UT26
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on January 11, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: zwf1
ORFNames: SPAC3A12.18, SPAC9.01
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329670; CAB08746.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T39186; T39186.
RefSeq NP_593344.2; -.
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase O00091.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-001953-MON; -.
Organism-specific databases
GeneDB_Spombe SPAC3A12.18; -.
Gene expression databases
ArrayExpress O00091; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0006010; Biological process: glucose 6-phosphate utilization (inferred by curator from GeneDB_SPombe).
GO:0006950; Biological process: response to stress (inferred from expression pattern from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
BLOCKS O00091.
Genome annotation databases
GeneID 2543200; -.
KEGG spo:SPAC3A12.18; -.
Other
ProtoNet O00091.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   500  500     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068106
ACT_SITE   247   247        Proton acceptor (By similarity). 
BINDING   20    20        NADP (By similarity). 
BINDING   52    52        NADP (By similarity). 
BINDING   185   185        Substrate (By similarity). 
BINDING   189   189        Substrate (By similarity). 
Sequence information
Length: 500 AA [This is the length of the unprocessed precursor] Molecular weight: 57204 Da [This is the MW of the unprocessed precursor] CRC64: 6706DD0847762A22 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSSANLSIKE NGAMVVFGAS GDLSKKKTFP ALFSLFSEGR LPKDIRIVGY ARSKIEHEDF 

        70         80         90        100        110        120 
LDRITQNIKI DEEDSQAKEK LEEFKKRCSY YRGSYDKPED FEGLNSHLCE REGDRSTHNR 

       130        140        150        160        170        180 
IFYLALPPDV FVSVATNLKK KCVPEKGIAR LVIEKPFGVD LKSAQELQSQ LAPLFDEKEI 

       190        200        210        220        230        240 
YRIDHYLGKE MVQNLVHLRF CNPVISHLWD KNSISSVQIT FKEPIGTEGR GGYFDSSTIV 

       250        260        270        280        290        300 
RDIVQNHLVQ ILTLLTMETP TTFSADDLRD EKVKVLRRTR LGDLKDIVLG QYVKSKDGKK 

       310        320        330        340        350        360 
PGYLDDETVP KGSRCPTYSA IPCFIDTERW RGVPFLLKAG KAMDIGKVEI RVQFKAAANG 

       370        380        390        400        410        420 
LFKDAYHNEL VIRVQPDEAI YFKMNIKQPG LSEAPLLTDL DLTYSRRFKN MKLHEAYEAL 

       430        440        450        460        470        480 
FLDAFAGDQS RFARIDELEC AWSLVDPLLK YMEEEKPVPE PYEYGSDGPE CLYSFLKKFG 

       490        500 
YIYDSPDYYD YPVMSVPSDH 

O00091 in FASTA format

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