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UniProtKB/Swiss-Prot entry Q9BX67


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name JAM3_HUMAN
Primary accession number Q9BX67
Secondary accession numbers Q8WWL8 Q96FL1
Integrated into Swiss-Prot on August 31, 2004
Sequence was last modified on June 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 62)
Name and origin of the protein
Protein name Junctional adhesion molecule C [Precursor]
Synonyms JAM-C
Junctional adhesion molecule 3
JAM-3
JAM-2
Gene name
Name: JAM3
ORFNames: UNQ859/PRO1868
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH JAM2, AND TISSUE SPECIFICITY.
TISSUE=Brain;
DOI=10.1074/jbc.M105972200; PubMed=11590146 [NCBI, ExPASy, EBI, Israel, Japan]
Arrate M.P., Rodriguez J.M., Tran T.M., Brock T.A., Cunningham S.A.;
"Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor.";
J. Biol. Chem. 276:45826-45832(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1182/blood.V98.13.3699; PubMed=11739175 [NCBI, ExPASy, EBI, Israel, Japan]
Aurrand-Lions M.A., Johnson-Leger C., Wong C., Du Pasquier L., Imhof B.A.;
"Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members.";
Blood 98:3699-3707(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1084/jem.20020267; PubMed=12208882 [NCBI, ExPASy, EBI, Israel, Japan]
Santoso S., Sachs U.J.H., Kroll H., Linder M., Ruf A., Preissner K.T., Chavakis T.;
"The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1.";
J. Exp. Med. 196:679-691(2002).
[4]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1006/geno.2002.6742; PubMed=11944976 [NCBI, ExPASy, EBI, Israel, Japan]
Phillips H.M., Renforth G.L., Spalluto C., Hearn T., Curtis A.R.J., Craven L., Havarani B., Clement-Jones M., English C., Stumper O., Salmon T., Hutchinson S., Jackson M.S., Wilson D.I.;
"Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis.";
Genomics 79:475-478(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PROTEIN SEQUENCE OF 32-46.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[9]
REVIEW, AND NOMENCLATURE.
DOI=10.1016/S1471-4906(03)00117-0; PubMed=12810109 [NCBI, ExPASy, EBI, Israel, Japan]
Muller W.A.;
"Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.";
Trends Immunol. 24:327-334(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF356518; AAK27221.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ344431; CAC69845.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF448478; AAM20925.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ416101; CAC94776.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK074769; BAC11195.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK075309; BAC11538.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358335; AAQ88701.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010690; AAH10690.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012147; AAH12147.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_116190.2; -.
UniGene Hs.150718
3D structure databases
HSSP O88792; 1F97. [HSSP ENTRY / PDB]
ModBase Q9BX67.
PTM databases
PhosphoSite Q9BX67; -.
Organism-specific databases
H-InvDB HIX0010295; -.
HGNC HGNC:15532; JAM3.
GenAtlas JAM3.
HPA HPA003417; -.
MIM 606871; gene. [NCBI / EBI]
PharmGKB PA29993; -.
GeneCards Q9BX67.
Gene expression databases
ArrayExpress Q9BX67; -.
CleanEx HS_JAM3; -.
GermOnline ENSG00000166086; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013106; Ig_V-set.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 2.
Pfam PF00047; ig; 1.
PF07686; V-set; 1.
Pfam graphical view of domain structure.
SMART SM00409; IG; 1.
SM00408; IGc2; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9BX67.
ProtoNet Q9BX67.
Genome annotation databases
Ensembl ENSG00000166086; Homo sapiens. [Contig view]
GeneID 83700; -.
KEGG hsa:83700; -.
Phylogenomic databases
HOGENOM Q9BX67; -.
HOVERGEN Q9BX67; -.
Other
NextBio 72688; -.
SOURCE JAM3; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Direct protein sequencing; Glycoprotein; Immunoglobulin domain; Membrane; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    31  31      
CHAIN   32   310  279     Junctional adhesion molecule C. PRO_0000015071
TOPO_DOM   32   241  210     Extracellular (Potential). 
TRANSMEM   242   262  21     Potential. 
TOPO_DOM   263   310  48     Cytoplasmic (Potential). 
DOMAIN   35   127  93     Ig-like V-type. 
DOMAIN   139   236  98     Ig-like C2-type. 
CARBOHYD   104   104        N-linked (GlcNAc...) (Potential). 
CARBOHYD   192   192        N-linked (GlcNAc...) (Potential). 
DISULFID   53   115        Potential. 
DISULFID   160   219        Potential. 
CONFLICT   136   136        Q -> R (in Ref. 7; AAH10690). 
Sequence information
Length: 310 AA [This is the length of the unprocessed precursor] Molecular weight: 35020 Da [This is the MW of the unprocessed precursor] CRC64: CE39ADF33EA1DAB9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALRRPPRLR LCARLPDFFL LLLFRGCLIG AVNLKSSNRT PVVQEFESVE LSCIITDSQT 

        70         80         90        100        110        120 
SDPRIEWKKI QDEQTTYVFF DNKIQGDLAG RAEILGKTSL KIWNVTRRDS ALYRCEVVAR 

       130        140        150        160        170        180 
NDRKEIDEIV IELTVQVKPV TPVCRVPKAV PVGKMATLHC QESEGHPRPH YSWYRNDVPL 

       190        200        210        220        230        240 
PTDSRANPRF RNSSFHLNSE TGTLVFTAVH KDDSGQYYCI ASNDAGSARC EEQEMEVYDL 

       250        260        270        280        290        300 
NIGGIIGGVL VVLAVLALIT LGICCAYRRG YFINNKQDGE SYKNPGKPDG VNYIRTDEEG 

       310 
DFRHKSSFVI 

Q9BX67 in FASTA format

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