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UniProtKB/Swiss-Prot entry Q6UWN8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ISK6_HUMAN
Primary accession number Q6UWN8
Secondary accession number Q8N5P0
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 41)
Name and origin of the protein
Protein name Serine protease inhibitor Kazal-type 6 [Precursor]
Synonyms None
Gene name
Name: SPINK6
ORFNames: UNQ844/PRO1782
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-36.
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 24-38.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY358716; AAQ89078.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC032003; AAH32003.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_995313.2; -.
UniGene Hs.334274
3D structure databases
ModBase Q6UWN8.
Protein family/group databases
MEROPS I01.015; -.
Organism-specific databases
H-InvDB HIX0005289; -.
HGNC HGNC:29486; SPINK6.
GenAtlas SPINK6.
PharmGKB PA134915474; -.
GeneCards Q6UWN8.
Gene expression databases
ArrayExpress Q6UWN8; -.
CleanEx HS_SPINK6; -.
GermOnline ENSG00000178172; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002350; Prot_inh_Kazal.
IPR001239; Prot_inh_Kazal-m.
Graphical view of domain structure.
Pfam PF00050; Kazal_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00290; KAZALINHBTR.
SMART SM00280; KAZAL; 1.
SMART graphical view of domain structure.
PROSITE PS00282; KAZAL; 1.
BLOCKS Q6UWN8.
ProtoNet Q6UWN8.
Genome annotation databases
Ensembl ENSG00000178172; Homo sapiens. [Contig view]
GeneID 404203; -.
KEGG hsa:404203; -.
Phylogenomic databases
HOGENOM Q6UWN8; -.
HOVERGEN Q6UWN8; -.
Other
NextBio 107819; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Polymorphism; Protease inhibitor; Pyrrolidone carboxylic acid; Secreted; Serine protease inhibitor; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
SIGNAL   1   23  23      
CHAIN   24   80  57     Serine protease inhibitor Kazal-type 6. PRO_0000016575
DOMAIN   28   80  53     Kazal-like. 
SITE   42   43  2     Reactive bond (By similarity). 
MOD_RES   24   24        Pyrrolidone carboxylic acid (By similarity). 
DISULFID   30   62        By similarity. 
DISULFID   40   59        By similarity. 
DISULFID   48   80        By similarity. 
VARIANT   36   36  1     P -> T (in dbSNP:rs12186491 [NCBI]). VAR_034020 
Sequence information
Length: 80 AA [This is the length of the unprocessed precursor] Molecular weight: 8585 Da [This is the MW of the unprocessed precursor] CRC64: C83CCA45AE69A900 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKLSGMFLLL SLALFCFLTG VFSQGGQVDC GEFQDPKVYC TRESNPHCGS DGQTYGNKCA 

        70         80 
FCKAIVKSGG KISLKHPGKC 

Q6UWN8 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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