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UniProtKB/Swiss-Prot entry O95633


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FSTL3_HUMAN
Primary accession number O95633
Secondary accession numbers None
Integrated into Swiss-Prot on October 10, 2002
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 68)
Name and origin of the protein
Protein name Follistatin-related protein 3 [Precursor]
Synonyms Follistatin-like 3
Follistatin-related gene protein
Gene name
Name: FSTL3
Synonyms: FLRG
ORFNames: UNQ674/PRO1308
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND CHROMOSOMAL TRANSLOCATION.
TISSUE=Placenta;
DOI=10.1038/sj.onc.1201807; PubMed=9671416 [NCBI, ExPASy, EBI, Israel, Japan]
Hayette S., Gadoux M., Martel S., Bertrand S., Tigaud I., Magaud J.-P., Rimokh R.;
"FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders.";
Oncogene 16:2949-2954(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 27-41.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[5]
TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
DOI=10.1210/en.142.8.3426; PubMed=11459787 [NCBI, ExPASy, EBI, Israel, Japan]
Tortoriello D.V., Sidis Y., Holtzman D.A., Holmes W.E., Schneyer A.L.;
"Human follistatin-related protein: a structural homologue of follistatin with nuclear localization.";
Endocrinology 142:3426-3434(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U76702; AAC64321.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358917; AAQ89276.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005839; AAH05839.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033119; AAH33119.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_005851.1; -.
UniGene Hs.529038
3D structure databases
PDB
3B4V; X-ray; 2.48 A; C/D/G/H=27-263.[ExPASy / RCSB / EBI]
PDBsum 3B4V; -.
ModBase O95633.
Protein family/group databases
MEROPS I01.968; -.
Organism-specific databases
H-InvDB HIX0014560; -.
HGNC HGNC:3973; FSTL3.
GenAtlas FSTL3.
MIM 605343; gene. [NCBI / EBI]
Orphanet 67038; B-cell chronic lymphocytic leukaemia.
PharmGKB PA28390; -.
GeneCards O95633.
Gene expression databases
ArrayExpress O95633; -.
CleanEx HS_FSTL3; -.
GermOnline ENSG00000070404; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003645; Fol_N.
IPR015204; Fol_N_sub.
IPR002350; Prot_inh_Kazal.
IPR011497; Prot_Inh_Kazal_2.
Graphical view of domain structure.
Pfam PF09120; EGF-like_subdom; 1.
PF00050; Kazal_1; 1.
PF07648; Kazal_2; 1.
Pfam graphical view of domain structure.
SMART SM00274; FOLN; 2.
SM00280; KAZAL; 2.
SMART graphical view of domain structure.
PROSITE PS00282; KAZAL; FALSE_NEG.
PS51364; TB; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O95633.
ProtoNet O95633.
Proteomic databases
PeptideAtlas O95633; -.
Genome annotation databases
Ensembl ENSG00000070404; Homo sapiens. [Contig view]
GeneID 10272; -.
KEGG hsa:10272; -.
Phylogenomic databases
HOGENOM O95633; -.
HOVERGEN O95633; -.
Other
NextBio 38914; -.
SOURCE FSTL3; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Chromosomal rearrangement; Direct protein sequencing; Glycoprotein; Nucleus; Proto-oncogene; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    26  26      
CHAIN   27   263  237     Follistatin-related protein 3. PRO_0000010115
DOMAIN   36   107  72     TB. 
DOMAIN   121   167  47     Kazal-like 1. 
DOMAIN   170   193  24     Follistatin-like 2. 
DOMAIN   195   243  49     Kazal-like 2. 
CARBOHYD   73    73        N-linked (GlcNAc...) (Potential). 
CARBOHYD   215   215        N-linked (GlcNAc...) (Potential). 
DISULFID   121   153        By similarity. 
DISULFID   125   146        By similarity. 
DISULFID   135   167        By similarity. 
DISULFID   195   229        By similarity. 
DISULFID   200   222        By similarity. 
DISULFID   211   243        By similarity. 
Sequence information
Length: 263 AA [This is the length of the unprocessed precursor] Molecular weight: 27663 Da [This is the MW of the unprocessed precursor] CRC64: 6A9AB86ADD4FD09C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRPGAPGPLW PLPWGALAWA VGFVSSMGSG NPAPGGVCWL QQGQEATCSL VLQTDVTRAE 

        70         80         90        100        110        120 
CCASGNIDTA WSNLTHPGNK INLLGFLGLV HCLPCKDSCD GVECGPGKAC RMLGGRPRCE 

       130        140        150        160        170        180 
CAPDCSGLPA RLQVCGSDGA TYRDECELRA ARCRGHPDLS VMYRGRCRKS CEHVVCPRPQ 

       190        200        210        220        230        240 
SCVVDQTGSA HCVVCRAAPC PVPSSPGQEL CGNNNVTYIS SCHMRQATCF LGRSIGVRHA 

       250        260 
GSCAGTPEEP PGGESAEEEE NFV 

O95633 in FASTA format

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