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UniProtKB/Swiss-Prot entry Q9H1M4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DB127_HUMAN
Primary accession number Q9H1M4
Secondary accession number Q14DW7
Integrated into Swiss-Prot on October 10, 2002
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 61)
Name and origin of the protein
Protein name Beta-defensin 127 [Precursor]
Synonyms Defensin, beta 127
Beta-defensin 27
DEFB-27
Gene name
Name: DEFB127
Synonyms: C20orf73, DEFB27
ORFNames: UNQ1956/PRO6071
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1016/S0888-7543(02)00034-4; PubMed=12620395 [NCBI, ExPASy, EBI, Israel, Japan]
Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.;
"Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.";
Genomics 81:175-183(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 19-77, AND IDENTIFICATION.
TISSUE=B-cell, Fetal lung, and Testis;
DOI=10.1073/pnas.042692699; PubMed=11854508 [NCBI, ExPASy, EBI, Israel, Japan]
Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.;
"Discovery of five conserved beta-defensin gene clusters using a computational search strategy.";
Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
[6]
PROTEIN SEQUENCE OF 21-35.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF525929; AAP47222.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358796; AAQ89156.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL360078; CAC17685.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069486; AAH69486.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC109395; AAI09396.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY122479; AAM93920.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_620713.1; -.
UniGene Hs.99362
3D structure databases
ModBase Q9H1M4.
Organism-specific databases
H-InvDB HIX0040533; -.
HGNC HGNC:16206; DEFB127.
GenAtlas DEFB127.
PharmGKB PA27247; -.
GeneCards Q9H1M4.
Gene expression databases
ArrayExpress Q9H1M4; -.
CleanEx HS_DEFB127; -.
GermOnline ENSG00000088782; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0042742; Biological process: defense response to bacterium (traceable author statement from UniProtKB).
GO:0045087; Biological process: innate immune response (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
BLOCKS Q9H1M4.
ProtoNet Q9H1M4.
Genome annotation databases
Ensembl ENSG00000088782; Homo sapiens. [Contig view]
GeneID 140850; -.
KEGG hsa:140850; -.
Phylogenomic databases
HOGENOM Q9H1M4; -.
HOVERGEN Q9H1M4; -.
Other
LinkHub Q9H1M4; -.
NextBio 84472; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin; Direct protein sequencing; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
SIGNAL   1   20  20      
PEPTIDE   21   63  43     Beta-defensin 127. PRO_0000007002
PROPEP   66   99  34     Potential. PRO_0000007003
DISULFID   24   53        By similarity. 
DISULFID   33   47        By similarity. 
DISULFID   37   54        By similarity. 
CONFLICT   31   31        G -> R (in Ref. 5; AAM93920). 
CONFLICT   71   77        RPKPATL -> SPKQHLH (in Ref. 5). 
Sequence information
Length: 99 AA [This is the length of the unprocessed precursor] Molecular weight: 11343 Da [This is the MW of the unprocessed precursor] CRC64: C9CBDB27D17AF380 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGLFMIIAIL LFQKPTVTEQ LKKCWNNYVQ GHCRKICRVN EVPEALCENG RYCCLNIKEL 

        70         80         90 
EACKKITKPP RPKPATLALT LQDYVTIIEN FPSLKTQST 

Q9H1M4 in FASTA format

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