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UniProtKB/Swiss-Prot entry B1IV68

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GHRA_ECOLC
Primary accession number B1IV68
Secondary accession numbers None
Integrated into Swiss-Prot on September 2, 2008
Sequence was last modified on April 29, 2008 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 8)
Name and origin of the protein
Protein name Glyoxylate/hydroxypyruvate reductase A
Synonyms EC 1.1.1.79
EC 1.1.1.81
2-ketoacid reductase
Gene name
Name: ghrA
OrderedLocusNames: EcolC_2566
From
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) [TaxID: 481805] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Ingram L., Richardson P.;
"Complete sequence of Escherichia coli C str. ATCC 8739.";
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000946; ACA78197.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001725524.1; -.
3D structure databases
ModBase B1IV68.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0048037; Molecular function: cofactor binding (inferred from electronic annotation from InterPro).
GO:0030267; Molecular function: glyoxylate reductase (NADP) activity (inferred from electronic annotation from HAMAP).
GO:0016618; Molecular function: hydroxypyruvate reductase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01666; -; 1.
PBIL [Tree]
InterPro IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; FALSE_NEG.
PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
PS00671; D_2_HYDROXYACID_DH_3; 1.
BLOCKS B1IV68.
ProtoNet B1IV68.
Genome annotation databases
GeneID 6065906; -.
GenomeReviews CP000946_GR; EcolC_2566.
KEGG ecl:EcolC_2566; -.
CMR B1IV68; EcolC_2566.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   312  312     Glyoxylate/hydroxypyruvate reductase A. PRO_0000348360
ACT_SITE   227   227        By similarity. 
ACT_SITE   275   275        Proton donor (By similarity). 
Sequence information
Length: 312 AA [This is the length of the unprocessed precursor] Molecular weight: 35357 Da [This is the MW of the unprocessed precursor] CRC64: 079D5F8A8FA58D05 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDIIFYHPTF DTQWWIEALR KAIPQARVRA WKSGDNDSAD YALVWHPPVE MLAGRDLKAV 

        70         80         90        100        110        120 
FALGAGVDSI LSKLQAHPEM LKPSVPLFRL EDTGMGEQMQ EYAVSQVLHW FRRFDDYRIQ 

       130        140        150        160        170        180 
QNSSHWQPLP EYHREDFTIG ILGAGVLGSK VAQSLQTWRF PLRCWSRTRK SWPGVQSFAG 

       190        200        210        220        230        240 
REELSAFLSQ CRVLINLLPN TPETVGIINQ QLLEKLPDGA YLLNLARGVH VVEDDLLAAL 

       250        260        270        280        290        300 
DSGKVKGAML DVFNREPLPP ESPLWQHPRV TITPHVAAIT RPAEAVEYIS RTIAQLEKGE 

       310 
RVCGQVDRAR GY
B1IV68 in FASTA format

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