ID   HGD_CAUSK               Reviewed;         427 AA.
AC   B0T816;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   04-NOV-2008, entry version 8.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=Caul_3652;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S.,
RA   Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; CP000927; ABZ72779.1; -; Genomic_DNA.
DR   RefSeq; YP_001685277.1; -.
DR   GeneID; 5901107; -.
DR   GenomeReviews; CP000927_GR; Caul_3652.
DR   KEGG; cak:Caul_3652; -.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    427       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000079265.
FT   METAL       328    328       Iron (By similarity).
FT   METAL       334    334       Iron (By similarity).
FT   METAL       364    364       Iron (By similarity).
SQ   SEQUENCE   427 AA;  46825 MW;  983B92E37D43B915 CRC64;
     MDLQYQSGFA NHFSTEAVPG ALPVGQNSPQ APPYGLYAEQ LSGTAFTAPR HENRRSWLYR
     LRPSAGHGPY APYVQERLKS GPFGAAVPTP NRLRWDPLEI PEAPLDFVDG LVTLAGNGDV
     ATQAGMAAHL YLANRSMIDR VFQNADGELL IVPQLGALRF VTELGVIDAA PGEVVVIPRG
     VRFRVELEGP VRGYVCENYG PMFRLPELGP IGSNGLANSR DFLTPVAAFE DVERPTEVIQ
     KFQGGLWTGT WDHSPLDVVA WHGNLAPYKY DLARFNTMGT VSFDHPDPSI FTVLTAPSEI
     PGTANVDFVI FPPRWMVAEH TFRPPWFHRN VMSEFMGLVT GAYDAKAGGF SPGGASLHNM
     MSDHGPDVAS HKAASEADLS PHKIEATMAF MFESRWVIRP TKYALETSEL QADYDACWTG
     FPKAKLP
//