[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA) (By similarity).
CATALYTIC ACTIVITY: 4-aminobutanal + NAD⁺ + H₂O = 4-aminobutanoate + NADH.
PATHWAY: Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1 .
SUBUNIT: Homotetramer (By similarity).
MISCELLANEOUS: 4-aminobutanal is also called gamma-aminobutyraldehyde.
SIMILARITY: Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000880; ABX21278.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001570420.1; -.

3D structure databases

ModBase

A9MQY3.

Ontologies

GO:0019145;	Molecular function: aminobutyraldehyde dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0051287;	Molecular function: NAD binding (inferred from electronic annotation from HAMAP).
GO:0016646;	Molecular function: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009447;	Biological process: putrescine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01275; -; 1.
PBIL [Tree]

InterPro

IPR017749; 1-pyrroline_dehydrogenase.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

ProtoNet

A9MQY3.

Genome annotation databases

GeneID

5764666; -.

GenomeReviews

CP000880_GR; SARI_01380.

KEGG

ses:SARI_01380; -.

CMR

A9MQY3; SARI_01380.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 474`	`474`	`Gamma-aminobutyraldehyde dehydrogenase.`	`PRO_1000085862`
`NP_BIND`	`172 175`	`4`	`NAD (By similarity).`
`NP_BIND`	`225 231`	`7`	`NAD (By similarity).`
`ACT_SITE`	`246 246`		`By similarity.`
`ACT_SITE`	`280 280`		`Nucleophile (By similarity).`
`BINDING`	`146 146`		`NAD; via carbonyl oxygen (By similarity).`
`BINDING`	`209 209`		`NAD (By similarity).`

Sequence information

Length: 474 AA [This is the length of the unprocessed precursor]

Molecular weight: 51121 Da [This is the MW of the unprocessed precursor]

CRC64: D6AE05BD4AF0527B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQYQLLINGA LVNGEGERQS VYNPATGEVI LEIAEASPKQ VDAAVLAADN AFTAWGQTTP 

        70         80         90        100        110        120 
KVRAECLLEL ADSIKQNALQ LAKLESQNCG KPLHCVINDE IPAIIDVFRF FAGAARCLNG 

       130        140        150        160        170        180 
LAAGEYLEGY TSMIRRDPVG VVASIAPWNY PLMMAAWKLA PALAAGNCVV IKPSEITPLT 

       190        200        210        220        230        240 
ALKLAALAKD IFPPGVINVL FGRGQTVGDA LTGHEKVRMV SLTGSIATGE HILRHTAPAI 

       250        260        270        280        290        300 
KRTHMELGGK APVIVFNDAD LDAVAQGIRT FGFYNAGQDC TAACRIYAQR GIYDTLVEKL 

       310        320        330        340        350        360 
GQAVSSLKMG APEDESTELG PLSSQAHLAR VTAAVEEAKA LSHIRVIAGG RQTGGKGYYF 

       370        380        390        400        410        420 
APTLLADAKQ EDAIVQREVF GPVVSITAFD DEEQVLRWAN ESRYGLASSV WTQDVGRAHR 

       430        440        450        460        470 
LSARLQYGCT WVNTHFMLVS EMPHGGQKQS GYGKDMSLYG LEDYTLVRHI MIKH

A9MQY3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools