[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity).
CATALYTIC ACTIVITY: N²-succinyl-L-arginine + 2 H₂O = N²-succinyl-L-ornithine + 2 NH₃ + CO₂.
PATHWAY: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5 .
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the succinylarginine dihydrolase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000880; ABX21564.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001570706.1; -.

3D structure databases

ModBase

A9MFF9.

Ontologies

GO:0009015;	Molecular function: N-succinylarginine dihydrolase activity (inferred from electronic annotation from HAMAP).
GO:0019544;	Biological process: arginine catabolic process to glutamate (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01172; -; 1.
PBIL [Tree]

InterPro

IPR007079; SuccinylArg_d-OHase_AstB.
Graphical view of domain structure.

Gene3D

G3DSA:3.75.10.20; SuccinylArg_di_hydro; 1.

TIGRFAMs

TIGR03241; arg_catab_astB; 1.

Genome annotation databases

GeneID

5763415; -.

GenomeReviews

CP000880_GR; SARI_01673.

KEGG

ses:SARI_01673; -.

CMR

A9MFF9; SARI_01673.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Arginine metabolism; Complete proteome; Hydrolase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 447`	`447`	`N-succinylarginine dihydrolase.`	`PRO_1000085395`
`REGION`	`19 28`	`10`	`Substrate binding (By similarity).`
`REGION`	`137 138`	`2`	`Substrate binding (By similarity).`
`ACT_SITE`	`174 174`		`By similarity.`
`ACT_SITE`	`248 248`		`By similarity.`
`ACT_SITE`	`365 365`		`Nucleophile (By similarity).`
`BINDING`	`110 110`		`Substrate (By similarity).`
`BINDING`	`212 212`		`Substrate (By similarity).`
`BINDING`	`250 250`		`Substrate (By similarity).`
`BINDING`	`359 359`		`Substrate (By similarity).`

Sequence information

Length: 447 AA [This is the length of the unprocessed precursor]

Molecular weight: 49316 Da [This is the MW of the unprocessed precursor]

CRC64: 41CDD136F125A709 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTAHEVNFDG LVGLTHHYAG LSFGNEASTR HRFQVSNPLL AVKQGLLKMK ALADAGFPQA 

        70         80         90        100        110        120 
VIPPHERPFI PALRQLGFSG NDEQILDKVA RQAPRWLSRV SSASPMWVAN AATVCPSADA 

       130        140        150        160        170        180 
LDGKVHLTVA NLNNKFHRSL EAPVTEALLR TIFRDESRFS LHSALPQVAL LGDEGAANHN 

       190        200        210        220        230        240 
RLGGEYGLAG VQLFVYGREE GNEKRPARYP ARQTREASEA VARLNQVNPQ QVIFAQQNPE 

       250        260        270        280        290        300 
AIDQGVFHND VIAVSNRQVL FCHEAAFARQ ERLINHLRTR VDGFMAIEVP ADEVSVSDAV 

       310        320        330        340        350        360 
ATYLFNSQLL SRDDGSMLLV LPQECQDHVG VWRYLNKLVA EDNPISAMQV FDLRESMANG 

       370        380        390        400        410        420 
GGPACLRLRV VLTEEEQRAV NPAVMMNDAL FTALNAWAER FYRDRLTAAD LADPLLLREG 

       430        440 
REALDVLTRL LDLGSVYPFQ QTGAADG

A9MFF9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools