FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000853; ABW17694.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001511690.1; -.

3D structure databases

ModBase

A8MFQ5.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GeneID

5677906; -.

GenomeReviews

CP000853_GR; Clos_0127.

KEGG

aoe:Clos_0127; -.

CMR

A8MFQ5; Clos_0127.

Other

ProtoNet

A8MFQ5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 413`	`413`		`Gamma-glutamyl phosphate reductase.`	`PRO_1000060836`

Sequence information

Length: 413 AA [This is the length of the unprocessed precursor]

Molecular weight: 45572 Da [This is the MW of the unprocessed precursor]

CRC64: 1972F76F31D71DBF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSYLIEQCKR LKEASYALGM ISTKDKDEAL RLIIDSIKRN KDDILAENDK DVLAAKEKGT 

        70         80         90        100        110        120 
KDSLIDRLKL TEDRIQGILE GIETIIGLKD PIWRSNDVWT LENGLTISKM TVPLGVIGII 

       130        140        150        160        170        180 
YESRPNVTVD AFSLALKSGN CILLRGSSSA IHSNKMIVSA IKEGLRRSKV SEDIIELIED 

       190        200        210        220        230        240 
TDRNVVKEML TLNEYIDVII PRGGADLIRF VVDHATVPTI ETGIGNCHIY VDESANLENA 

       250        260        270        280        290        300 
IQIITNAKIQ RPGVCNACET TLIHEDIAPK FLPMLAAALK DKVELKGCPR TREIIQAAEA 

       310        320        330        340        350        360 
TDMDWAEEYL DYILAVKVVS NVDEAIGHIQ AYGTKHSEAI ITENYTNANY FLRRVDAAAV 

       370        380        390        400        410 
YVNASTRFTD GGAFGFGGEM GISTQKTHAR GPMGLNELVT MKYTVVGNGQ IRQ

A8MFQ5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools