[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Plays a role in nitrite reduction (By similarity).
CATALYTIC ACTIVITY: NH₃ + 2 H₂O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H⁺.
COFACTOR: Binds 1 calcium ion per monomer (By similarity).
COFACTOR: Binds 5 heme groups covalently per monomer (By similarity).
PATHWAY: Nitrogen metabolism; nitrate reduction (assimilation).
SUBCELLULAR LOCATION: Periplasm (By similarity).
SIMILARITY: Belongs to the cytochrome c-552 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000822; ABV14890.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001455325.1; -.

3D structure databases

ModBase

A8AN26.

Ontologies

GO:0042597;	Cellular component: periplasmic space (inferred from electronic annotation from HAMAP).
GO:0005509;	Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0042279;	Molecular function: nitrite reductase (cytochrome, ammonia-forming) activity (inferred from electronic annotation from HAMAP).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006807;	Biological process: nitrogen compound metabolic process (inferred from electronic annotation from HAMAP).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_01182; -; 1.
PBIL [Tree]

InterPro

IPR003321; Cyt_c552.
IPR017570; Cytc_552_NO2Rdtase_formate-dep.
IPR011031; Multihaem_cyt.
Graphical view of domain structure.

Pfam

PF02335; Cytochrom_C552; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000243; Cyt_c552; 1.

PROSITE

PS51008; MULTIHEME_CYTC; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

A8AN26.

Genome annotation databases

GeneID

5580866; -.

GenomeReviews

CP000822_GR; CKO_03814.

KEGG

cko:CKO_03814; -.

CMR

A8AN26; CKO_03814.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calcium; Complete proteome; Electron transport; Heme; Iron; Metal-binding; Oxidoreductase; Periplasm; Signal; Transport.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 26`	`26`	`Potential.`
`CHAIN`	`27 478`	`452`	`Cytochrome c-552.`	`PRO_1000065800`
`METAL`	`94 94`		`Iron (heme 3 axial ligand) (By similarity).`
`METAL`	`126 126`		`Iron (heme 1 axial ligand) (By similarity).`
`METAL`	`164 164`		`Iron (heme 2 axial ligand) (By similarity).`
`METAL`	`213 213`		`Iron (heme 3 axial ligand) (By similarity).`
`METAL`	`215 215`		`Calcium (By similarity).`
`METAL`	`216 216`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`261 261`		`Calcium; via carbonyl oxygen (By similarity).`
`METAL`	`263 263`		`Calcium (By similarity).`
`METAL`	`275 275`		`Iron (heme 5 axial ligand) (By similarity).`
`METAL`	`286 286`		`Iron (heme 4 axial ligand) (By similarity).`
`METAL`	`301 301`		`Iron (heme 2 axial ligand) (By similarity).`
`METAL`	`318 318`		`Iron (heme 5 axial ligand) (By similarity).`
`METAL`	`393 393`		`Iron (heme 4 axial ligand) (By similarity).`
`BINDING`	`122 122`		`Heme 1 (covalent) (By similarity).`
`BINDING`	`125 125`		`Heme 1 (covalent) (By similarity).`
`BINDING`	`160 160`		`Heme 2 (covalent) (By similarity).`
`BINDING`	`163 163`		`Heme 2 (covalent) (By similarity).`
`BINDING`	`209 209`		`Heme 3 (covalent) (By similarity).`
`BINDING`	`212 212`		`Heme 3 (covalent) (By similarity).`
`BINDING`	`216 216`		`Substrate (By similarity).`
`BINDING`	`264 264`		`Substrate (By similarity).`
`BINDING`	`282 282`		`Heme 4 (covalent) (By similarity).`
`BINDING`	`285 285`		`Heme 4 (covalent) (By similarity).`
`BINDING`	`314 314`		`Heme 5 (covalent) (By similarity).`
`BINDING`	`317 317`		`Heme 5 (covalent) (By similarity).`

Sequence information

Length: 478 AA [This is the length of the unprocessed precursor]

Molecular weight: 53688 Da [This is the MW of the unprocessed precursor]

CRC64: 1EBC5B27503109E8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MARTILRARR FFSLILPFFF ISSVYAEQTS VPAKTVTVEA KNETFAPQHP DQYLSWKATS 

        70         80         90        100        110        120 
EQSTREDALA EDPRLVILWA GYPFSRDYNK PRGHAYAVTD VRETLRTGAP KNAEDGPLPM 

       130        140        150        160        170        180 
ACWSCKSPDV ARLIQKDGED GYFHGKWARG GPEIVNALGC ADCHNTASDD FAKGKPALTL 

       190        200        210        220        230        240 
SRPYAERAME TIGKPFDKAS RFDQQSMVCG QCHVEYYFDG KNKAVKFPWD EGTKVEDMEK 

       250        260        270        280        290        300 
YYDAIAFSDW TNPLSKTPML KAQHPEYETW SVGIHGKNNV TCIDCHMPKV QNAEGKLYTD 

       310        320        330        340        350        360 
HKIGNPFDNF AQTCANCHTQ DKASLQKVVA ERKQAIHDLK IKVEDQLVHA HFEAKAAWDA 

       370        380        390        400        410        420 
GATEAEMKPI LDDIRHAQWR WDLAIASHGI HMHAPDEGLR MLGGAMDKAA DARTKLVRLL 

       430        440        450        460        470 
GSKGITHEIP LPDISTKEKA QKAIGLNMQQ INAEKQDFIK TVIPQWEDQA RKNGLLSQ

A8AN26 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools