[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity).
CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1 .
SIMILARITY: Belongs to the GMC oxidoreductase family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000822; ABV13693.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001454129.1; -.

3D structure databases

ModBase

A8AJN0.

Ontologies

GO:0008812;	Molecular function: choline dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00750; -; 1.
PBIL [Tree]

InterPro

IPR011533; Choline_dehydrogenase.
IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.

Pfam

PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000137; Alcohol_oxidase; 1.

TIGRFAMs

TIGR01810; betA; 1.

PROSITE

PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; 1.

BLOCKS

A8AJN0.

Genome annotation databases

GeneID

5582871; -.

GenomeReviews

CP000822_GR; CKO_02584.

KEGG

cko:CKO_02584; -.

CMR

A8AJN0; CKO_02584.

Other

ProtoNet

A8AJN0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; FAD; Flavoprotein; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 558`	`558`	`Choline dehydrogenase.`	`PRO_1000046562`
`NP_BIND`	`4 33`	`30`	`FAD (Probable).`
`ACT_SITE`	`473 473`		`By similarity.`

Sequence information

Length: 558 AA [This is the length of the unprocessed precursor]

Molecular weight: 61772 Da [This is the MW of the unprocessed precursor]

CRC64: D4CBD3AB65A06120 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHFDYIIIGA GSAGNVLATR LTEDSDTTVL LLEAGGPDYR ADFRTQMPAA LAFPLQGKRY 

        70         80         90        100        110        120 
NWAYETEPEP HMNYRRMECG RGKGLGGSSL INGMCYIRGN AMDLDNWAQE PGLEHWSYLN 

       130        140        150        160        170        180 
CLPYYRKAET RDIGPNDYHG GDGPVSVATP KHNNNPLFHA MIEAGVQAGY PRTDDLNGYQ 

       190        200        210        220        230        240 
QEGFGPMDRT VTPQGRRAST ARGYLDQAKG RPNLTIITHA LTDHILFEGK KASGVEWLEG 

       250        260        270        280        290        300 
DSTIPTRAMA RKEVLLCAGA IASPQILQRS GVGDASLLKA FDIPLVHHLP GVGENLQDHL 

       310        320        330        340        350        360 
EMYLQYECKE PVSLYPALQW WNQPKIGAEW LFGGTGVGAS NHFEAGGFIR SSEAFSWPNI 

       370        380        390        400        410        420 
QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVHIK SRDPREHPAI LFNYMSTGQD 

       430        440        450        460        470        480 
WQEFRDAIRI TREIINQPAL DKYRGREISP GITCQTDEQL DAFVRDHAET AFHPCGTCKM 

       490        500        510        520        530        540 
GYDEMAVVDG EGRVHGVENL RVVDASIMPQ IITGNLNATT IMIGEKMADA IRGREPLAKS 

       550 
TASYYVAGDA PVRQPPLR

A8AJN0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools