[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate (By similarity).
CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD⁺ + H₂O = N-succinyl-L-glutamate + NADH.
PATHWAY: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

CP000822; ABV12901.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001453337.1; -.

3D structure databases

ModBase

A8AHD8.

Ontologies

GO:0019544;	Biological process: arginine catabolic process to glutamate (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01174; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR017649; SuccinylGlu_semiald_DH_AstD.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

A8AHD8.

Genome annotation databases

GeneID

5583741; -.

GenomeReviews

CP000822_GR; CKO_01772.

KEGG

cko:CKO_01772; -.

CMR

A8AHD8; CKO_01772.

Other

ProtoNet

A8AHD8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Arginine metabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 492`	`492`	`N-succinylglutamate 5-semialdehyde dehydrogenase.`	`PRO_1000065753`
`NP_BIND`	`220 225`	`6`	`NAD (By similarity).`
`ACT_SITE`	`243 243`		`By similarity.`
`ACT_SITE`	`277 277`		`By similarity.`

Sequence information

Length: 492 AA [This is the length of the unprocessed precursor]

Molecular weight: 53219 Da [This is the MW of the unprocessed precursor]

CRC64: B925C31EB1D0F188 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTLWINGDWV TGQGERRVKT NPVNGEVLWQ GSDADATQVA EAGRAARAAF PTWARLPFAA 

        70         80         90        100        110        120 
RQAIVEKFAA LLEVHKAELT AIIARETGKP CWEAATEVTA MINKIAISVK AYHARTGEQQ 

       130        140        150        160        170        180 
SELPDGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLIFKPS ELTPWTGEAV 

       190        200        210        220        230        240 
MKLWQQAGLP PGVLNLVQGG RETGQALSAL DALDGLLFTG SANTGYQLHR QLSGQPEKIL 

       250        260        270        280        290        300 
ALEMGGNNPL IIENPEDIDA AVHLTIQSAF VTAGQRCTCA RRLLVKRGEQ GDAFLARLLE 

       310        320        330        340        350        360 
VSQRLTPGEW DDEPQPFIGG LISEPAARHV YEAWQRLEAM GGRTLLAPRM LKAGTSLLTP 

       370        380        390        400        410        420 
GIIEMTGVKQ VPDDEVFGPL LSVWRYERFD EAIRMANNTR FGLSCGLVSP DRKQFDQLLL 

       430        440        450        460        470        480 
EARAGIVNWN KPLTGAASTA PFGGVGASGN HRPSAWYAAD YCAWPMASLE SPTLVLPDSL 

       490 
SPGLDFSREE PV

A8AHD8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools