[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Rasko D.A., Rosovitz M.J., Brinkley C., Myers G.S.A., Seshadri R., Cer R.Z., Jiang L., Ravel J.; Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the terminal reaction in meta-cleavage pathways, that is, the transformation of acetaldehyde into acetyl coenzyme A (By similarity).
CATALYTIC ACTIVITY: Acetaldehyde + CoA + NAD⁺ = acetyl-CoA + NADH.
PATHWAY: Aromatic compound metabolism; 3-phenylpropionic acid degradation .
SUBUNIT: Interacts with mhpE (By similarity).
SIMILARITY: Belongs to the acetaldehyde dehydrogenase family. MhpF subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000800; ABV17887.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001461527.1; -.

3D structure databases

ModBase

A7ZI98.

Ontologies

GO:0008774;	Molecular function: acetaldehyde dehydrogenase (acetylating) activity (inferred from electronic annotation from HAMAP).
GO:0019439;	Biological process: aromatic compound catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01657; -; 1.
PBIL [Tree]

InterPro

IPR003361; Acetylald_dehydrogenase.
IPR015426; Acetylald_DHase_C.
IPR000534; Semialdehyde_DHase_NAD-bd.
Graphical view of domain structure.

PANTHER

PTHR21123; Acetylald_dh; 1.

Pfam

PF09290; AcetDehyd-dimer; 1.
PF01118; Semialdhyde_dh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF015689; Actaldh_dh_actl; 1.

TIGRFAMs

TIGR03215; ac_ald_DH_ac; 1.

BLOCKS

A7ZI98.

Genome annotation databases

GeneID

5586084; -.

GenomeReviews

CP000800_GR; EcE24377A_0375.

KEGG

ecw:EcE24377A_0375; -.

CMR

A7ZI98; EcE24377A_0375.

Other

ProtoNet

A7ZI98.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 316`	`316`		`Acetaldehyde dehydrogenase.`	`PRO_0000337979`

Sequence information

Length: 316 AA [This is the length of the unprocessed precursor]

Molecular weight: 33442 Da [This is the MW of the unprocessed precursor]

CRC64: A6918BDA5EF4876B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRM GVATTHEGVI 

        70         80         90        100        110        120 
GLMNMPEFAD IDIVFDATSA GAHVKNDAAL REAKPDIRLI DLTPAAIGPY CVPVVNLEAN 

       130        140        150        160        170        180 
VDQLNVNMVT CGGQATIPMV AAVSRVARVH YAEIIASIAS KSAGPGTRAN IDEFTETTSR 

       190        200        210        220        230        240 
AIEVVGGAAK GKAIIVLNPA EPPLMMRDTV YVLSDEASQD DIEASINEMA EAVQAYVPGY 

       250        260        270        280        290        300 
RLKQRVQFEV IPQDKPVNLP GVGQFSGLKT AVWLEVEGAA HYLPAYAGNL DIMTSSALAT 

       310 
AEKMAQSLAR KAGEAA

A7ZI98 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools