[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Rasko D.A., Rosovitz M.J., Brinkley C., Myers G.S.A., Seshadri R., Cer R.Z., Jiang L., Ravel J.; Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Betaine aldehyde + NAD⁺ + H₂O = betaine + NADH.
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000800; ABV18550.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001461480.1; -.

3D structure databases

ModBase

A7ZI51.

Ontologies

GO:0008802;	Molecular function: betaine-aldehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00804; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR011264; Betaine_Ald_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01804; BADH; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

A7ZI51.

Genome annotation databases

GeneID

5588779; -.

GenomeReviews

CP000800_GR; EcE24377A_0327.

KEGG

ecw:EcE24377A_0327; -.

NMPDR

fig|331111.3.peg.2879; -.

CMR

A7ZI51; EcE24377A_0327.

Other

ProtoNet

A7ZI51.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 490`	`490`	`Betaine aldehyde dehydrogenase.`	`PRO_1000062268`
`NP_BIND`	`229 234`	`6`	`NAD (By similarity).`
`ACT_SITE`	`252 252`		`By similarity.`
`ACT_SITE`	`286 286`		`By similarity.`

Sequence information

Length: 490 AA [This is the length of the unprocessed precursor]

Molecular weight: 52933 Da [This is the MW of the unprocessed precursor]

CRC64: 7FBCC44C933FBB2D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSRMAEQQLY IHGGYTSATS GRTFETINPA NGNVLATVQA AGREDVDRAV KSAQQGQKIW 

        70         80         90        100        110        120 
AAMTAMERSR ILRRAVDILR ERNDELAKLE TLDTGKAYSE TSTVDIVTGA DVLEYYAGLI 

       130        140        150        160        170        180 
PSLEGSQIPL RETSFVYTRR EPLGVVAGIG AWNYPIQIAL WKSAPALAAG NAMIFKPSEV 

       190        200        210        220        230        240 
TPLTALKLAE IYSEAGLPDG VFNVLPGVGA ETGQYLTEHP GIAKVSFTGG VASGKKVMAN 

       250        260        270        280        290        300 
SAASSLKEVT MELGGKSPLI VFDDADLDLA ADIAMMANFF SSGQVCTNGT RVFVPAKCKA 

       310        320        330        340        350        360 
AFEQKILARV ERIRAGDVFD PQTNFGPLVS FPHRDNVLRY IVKGKEEGAR VLCGGDVLKG 

       370        380        390        400        410        420 
DGLDNGAWVA PTVFTDCSDE MTIVREEIFG PVMSILTYES EEEVIRRAND TDYGLAAGIV 

       430        440        450        460        470        480 
TADLNRAHRV IHQLEAGICW INTWGESPAE MPVGGYKHSG IGRENGVMTL QSYTQVKSIQ 

       490 
VEMAKFQSIF

A7ZI51 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools