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UniProtKB/Swiss-Prot entry A7YWE4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL4A1_BOVIN
Primary accession number A7YWE4
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 2008
Sequence was last modified on October 23, 2007 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 10)
Name and origin of the protein
Protein name Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [Precursor]
Synonyms P5C dehydrogenase
EC 1.5.1.12
Aldehyde dehydrogenase family 4 member A1
Gene name
Name: ALDH4A1
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford;
TISSUE=Ascending colon;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC134524; AAI34525.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001099116.1; -.
UniGene Bt.3248
3D structure databases
ModBase A7YWE4.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005931; d-1-pyrroline-5-COlate_DHase-1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01236; D1pyr5carbox1; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS A7YWE4.
Genome annotation databases
Ensembl ENSBTAG00000030335; Bos taurus. [Contig view]
GeneID 100126042; -.
KEGG bta:100126042; -.
Other
ProtoNet A7YWE4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Proline metabolism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    24  24     Mitochondrion (By similarity). 
CHAIN   25   563  539     Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial. PRO_0000342182
NP_BIND   296   301  6     NAD (By similarity). 
ACT_SITE   314   314        Proton acceptor (By similarity). 
ACT_SITE   348   348        Nucleophile (By similarity). 
SITE   211   211  1     Transition state stabilizer (By similarity). 
MOD_RES   99    99        N6-acetyllysine (By similarity). 
MOD_RES   114   114        N6-acetyllysine (By similarity). 
MOD_RES   402   402        N6-acetyllysine (By similarity). 
MOD_RES   505   505        Phosphotyrosine (By similarity). 
Sequence information
Length: 563 AA [This is the length of the unprocessed precursor] Molecular weight: 61495 Da [This is the MW of the unprocessed precursor] CRC64: E45B568B4844FEF0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLLRSAALCR ALLARRGRAA GLCRRCVSSL QVANEPVLAF TQGSPERDAL QKALKELKGR 

        70         80         90        100        110        120 
TEAIPCVVGD EEVWTSDVRY QASPFNHGHK VAKFCYADKA LLHRAIGAAL AARKEWDLKP 

       130        140        150        160        170        180 
VADRAQVFLK AADLLSGPRR AEVLAKTMVG QGKTVIQAEI DAAAELIDFF RFNAKFAMEL 

       190        200        210        220        230        240 
EGEQPLSVPP STNSMLYRGL EGFVAAISPF NFTAIGGNLA GAPALMGNVV LWKPSDTAML 

       250        260        270        280        290        300 
ASYAVYRILR EAGLPPNIIQ FVPADGPTFG DTVTSSEHLC GINFTGSVPT FKHLWKQVAQ 

       310        320        330        340        350        360 
NLDRFRTFPR LAGECGGKNF HFVHRSADVD SVVSGTLRSA FEYGGQKCSA CSRLYAPRSL 

       370        380        390        400        410        420 
WPQIKGRLLE ELGGIKVGNP AEDFGTFFSA VIDAKSFGRI RKWLEHARSS PSLTILAGGH 

       430        440        450        460        470        480 
CDDSVGYFVE PCIVETKDPQ DPIMKEEIFG PVLAVYVYPD EEYKETLRLV DSTTSYGLTG 

       490        500        510        520        530        540 
AVFAQDKDVL REATELLRHA AGNFYINDKS TGSVVGQQPF GGARASGTND KPGGPHYVLR 

       550        560 
WTSPQVIKET HGPLGDWRYP YMQ
A7YWE4 in FASTA format

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