[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate (By similarity).
CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD⁺ + H₂O = N-succinyl-L-glutamate + NADH.
PATHWAY: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000783; ABU77404.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001438240.1; -.

3D structure databases

ModBase

A7MNV8.

Ontologies

GO:0019544;	Biological process: arginine catabolic process to glutamate (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01174; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR017649; SuccinylGlu_semiald_DH_AstD.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

A7MNV8.

Genome annotation databases

GeneID

5550034; -.

GenomeReviews

CP000783_GR; ESA_02155.

KEGG

esa:ESA_02155; -.

CMR

A7MNV8; ESA_02155.

Other

ProtoNet

A7MNV8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Arginine metabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 492`	`492`	`N-succinylglutamate 5-semialdehyde dehydrogenase.`	`PRO_1000065757`
`NP_BIND`	`220 225`	`6`	`NAD (By similarity).`
`ACT_SITE`	`243 243`		`By similarity.`
`ACT_SITE`	`277 277`		`By similarity.`

Sequence information

Length: 492 AA [This is the length of the unprocessed precursor]

Molecular weight: 52433 Da [This is the MW of the unprocessed precursor]

CRC64: 71E87D01B57FE4BC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLWINGEWT TGQGEALEKR DPVGSGLLWQ GHAADDAQVQ AACAAARAAF PAWAKRPFAD 

        70         80         90        100        110        120 
RQAIAEKFAA LLEANKTELT RIIALETSKP RWEAATEVTA MINKVGISLK AYQTRTGEQH 

       130        140        150        160        170        180 
SPMPDGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLVFKPS ELTPHTGEAV 

       190        200        210        220        230        240 
MKLWEQAGLP AGVLNLVQGA RATGQALSAR PELDGLLFTG SAGTGYQLHR QLAGQPEKIL 

       250        260        270        280        290        300 
ALEMGGNNPL IVEDPDDIDG AVHLAIQSAF ITAGQRCTCA RRLLVKRGAA GDAFLARLVE 

       310        320        330        340        350        360 
IAGRLRPDRW DAEPQPFMGG LISAQAAERV LEAWQGHLSR GGKPLLTPAL VQAGSSLLTP 

       370        380        390        400        410        420 
GIIELTGVRD VPDEEVFGPL LGVWRYDDFD EAITLANATR YGLSCGLISP VREKFDQLLL 

       430        440        450        460        470        480 
EARAGIVNWN KPLTGAASTA PFGGVGASGN HRPSAWYAAD YCAWPMASLE SPTFALPQTL 

       490 
NPGLDFSGKE QA

A7MNV8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools