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UniProtKB/Swiss-Prot entry A7MN74

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_ENTS8
Primary accession number A7MN74
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on March 18, 2008 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 11)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: ESA_02975
From
Enterobacter sakazakii (strain ATCC BAA-894) [TaxID: 290339] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Cronobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.;
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000783; ABU78204.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001439040.1; -.
3D structure databases
ModBase A7MN74.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS A7MN74.
Genome annotation databases
GeneID 5548577; -.
GenomeReviews CP000783_GR; ESA_02975.
KEGG esa:ESA_02975; -.
CMR A7MN74; ESA_02975.
Other
ProtoNet A7MN74.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   566  566     NAD-dependent malic enzyme. PRO_0000323536
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   419   419        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 566 AA [This is the length of the unprocessed precursor] Molecular weight: 63030 Da [This is the MW of the unprocessed precursor] CRC64: 12A2D79AE81592B0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEIKHKKNRS LYIPYAGPVL LEFPLLNKGS AFSMEERSNF NLLGLLPEVV ETIEEQAERA 

        70         80         90        100        110        120 
WRQFEDFKTD IDKHIYLRNI QDTNETLFYR LLENHLEVMM PIIYTPTVGS ACERFSEIYR 

       130        140        150        160        170        180 
RARGVFISWP NRHNMDDILQ NVPIHNIKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
ACGGISPAYT LPIVLDVGTN NQQLLNDPLY MGWRHPRITD DEYYAFVDDF IQAVKQRWPN 

       250        260        270        280        290        300 
VLLQFEDFAQ KNAMPLLERY RDEICCFNDD IQGTAAVTLG TLIAASRAAG SQLSEQKIVF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIIAWMRT EGGLSDEQAR ARVFMVDRFG LLTDNMPNLL SFQSKLVQKR 

       370        380        390        400        410        420 
DSLKGWDTQS DSISLLDVVR NAKPDILIGV SGQTGLFTEE IIREMHKHCA RPIVMPLSNP 

       430        440        450        460        470        480 
TSRVEATPHD ILNWTDGAAL VATGSPFQPV TVKEKTYPIA QCNNAYIFPG IGLGIISSGA 

       490        500        510        520        530        540 
LRVTDEMMMA ASEALASHSP LVNTGSGLVL PPLTDIQQVS KDIAFAVGKM AQQQGVAVKT 

       550        560 
SAEALLQAIE ENFWLPEYRS YRRTSI
A7MN74 in FASTA format

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