[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000783; ABU78223.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001439059.1; -.

3D structure databases

ModBase

A7MN58.

Ontologies

GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR016084; Haem_Oase-like_multi-hlx.
IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

BLOCKS

A7MN58.

Genome annotation databases

GeneID

5548763; -.

GenomeReviews

CP000783_GR; ESA_02994.

KEGG

esa:ESA_02994; -.

CMR

A7MN58; ESA_02994.

Other

ProtoNet

A7MN58.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 251`	`251`		`Pyrroloquinoline-quinone synthase.`	`PRO_1000061668`

Sequence information

Length: 251 AA [This is the length of the unprocessed precursor]

Molecular weight: 29395 Da [This is the MW of the unprocessed precursor]

CRC64: 60024EFC6E018056 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTEQRLLTPD EFEAALRAKG AFYHIHHPYH IAMHNGEATR EQIQGWVANR FYYQTSIPIK 

        70         80         90        100        110        120 
DAAIMANCPH PEVRRQWVQR ILDHDGYDGS EGGIEAWLRL GEAVGLSRES LLSEERVLPG 

       130        140        150        160        170        180 
VRFAVDAYVN FARRACWEEA ACSSLTELFA PQIHQARLDS WPQHYTWIEA EGYDYFRSRL 

       190        200        210        220        230        240 
NQARRDVEHG LSLALEYCNT MERQQRMLEI LQFKLDILWS MLDAMTMAYT LDRAPYHTVT 

       250 
REAVWHKRRL V

A7MN58 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools