[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.; "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."; Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000767; EAT99669.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001407389.1; -.

3D structure databases

ModBase

A7GVZ7.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 2.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GeneID

5406596; -.

GenomeReviews

CP000767_GR; Ccur92_00850.

KEGG

ccv:CCV52592_0754; -.

CMR

A7GVZ7; Ccur92_00850.

Other

ProtoNet

A7GVZ7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 442`	`442`		`Gamma-glutamyl phosphate reductase.`	`PRO_1000060838`

Sequence information

Length: 442 AA [This is the length of the unprocessed precursor]

Molecular weight: 47155 Da [This is the MW of the unprocessed precursor]

CRC64: 9D68299F6CB79BA2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSEILNIAKA AKASCEQLLN LSAQAKSQIL NAVADELVRQ KEAIKAANLL DLKAGENAGL 

        70         80         90        100        110        120 
SAALLDRLEL TDARIEAMAN GVREVAKFDE VVGEVLGGWR HPNGMQITKI RVPLGVLGII 

       130        140        150        160        170        180 
YESRPNVSID AAALALKSGN AVILRGSAAA ISSNKFLVNL FNETGAKFGL PKGAVALVES 

       190        200        210        220        230        240 
TDKEAVGEMI KMHEFIDVLI PRGGKNLKDF IIQNATIPVI ETGAGVCHIF VDESADVREA 

       250        260        270        280        290        300 
VEIIKNAKTQ RPSTCNSVEC VLLHERVAVK VLTSLARELD GVQLRVHEDL WAKFGENLGE 

       310        320        330        340        350        360 
ISGDLDANLS GLKAEVKIGE SSNGAQLVKA DESDFGTEFL SLVLAVKCVS GVAEAVSYIN 

       370        380        390        400        410        420 
SHSTHHSDAI LSRDYANIER FLNAVDSAVV YANASTRFSD GGEFGFGGEI GISTQKLHAR 

       430        440 
GPMGVRELTT SKYVVRGDGQ IR

A7GVZ7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools