ID   BETA_OCHA4              Reviewed;         549 AA.
AC   A6X2G7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-NOV-2008, entry version 12.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=Oant_2709;
OS   Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / NCTC 12168).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Ochrobactrum.
OX   NCBI_TaxID=439375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Garcia E., Richardson P.;
RT   "Complete sequence of chromosome 1 of Ochrobactrum anthropi ATCC
RT   49188.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000758; ABS15421.1; -; Genomic_DNA.
DR   RefSeq; YP_001371250.1; -.
DR   GeneID; 5379209; -.
DR   GenomeReviews; CP000758_GR; Oant_2709.
DR   KEGG; oan:Oant_2709; -.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    549       Choline dehydrogenase.
FT                                /FTId=PRO_1000046565.
FT   NP_BIND       4     33       FAD (Probable).
FT   ACT_SITE    465    465       By similarity.
SQ   SEQUENCE   549 AA;  60562 MW;  5A6C3FAAD0DC6C64 CRC64;
     MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS FPMNMETYDW
     GFSTEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAR DYDHWSESGA RGWAYADVLP
     YFKRMENSSG GQEGWRGTNG PLYIQRGKRD NPLFHAFVEA GHEAGFEVTE DYNGEKQEGF
     GPMEQTIHNG RRWSAANAYL KPALKRPNVK LVKGLARKIV LEGKRAVGVE IEAGRSFSTI
     RARREVIIAA SSINSPKLLM LSGIGPAAQL KEHGIEVVAD RPGVGQNLQD HLEVYIQQEC
     TQPITLYSKL NLFSKAKIGA EWLFFKTGDG ATNHFESAAF LRSKAGVEYP DIQYHFLPVA
     IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP VIKFNYMSHE DDWADFRHCV
     RLTREIFGQA AFNPYRGAEI QPGAHVQSDD EIDNFIKEHV ESAFHPCGTC KMGAVDDPMA
     VVDAECRVIG VEGLRVADSS IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSDQEPWI
     NPRWQVSDR
//