NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Garcia E., Richardson P.;
"Complete sequence of chromosome 1 of Ochrobactrum anthropi ATCC 49188.";
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity).
CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1 .
SIMILARITY: Belongs to the GMC oxidoreductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000758; ABS15421.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001371250.1; -.

3D structure databases

ModBase

A6X2G7.

Ontologies

GO:0008812;	Molecular function: choline dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00750; -; 1.
PBIL [Tree]

InterPro

IPR011533; Choline_dehydrogenase.
IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.

Pfam

PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000137; Alcohol_oxidase; 1.

TIGRFAMs

TIGR01810; betA; 1.

PROSITE

PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; 1.

BLOCKS

A6X2G7.

Genome annotation databases

GeneID

5379209; -.

GenomeReviews

CP000758_GR; Oant_2709.

KEGG

oan:Oant_2709; -.

CMR

A6X2G7; Oant_2709.

Other

ProtoNet

A6X2G7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; FAD; Flavoprotein; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 549`	`549`	`Choline dehydrogenase.`	`PRO_1000046565`
`NP_BIND`	`4 33`	`30`	`FAD (Probable).`
`ACT_SITE`	`465 465`		`By similarity.`

Sequence information

Length: 549 AA [This is the length of the unprocessed precursor]

Molecular weight: 60562 Da [This is the MW of the unprocessed precursor]

CRC64: 5A6C3FAAD0DC6C64 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS FPMNMETYDW 

        70         80         90        100        110        120 
GFSTEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAR DYDHWSESGA RGWAYADVLP 

       130        140        150        160        170        180 
YFKRMENSSG GQEGWRGTNG PLYIQRGKRD NPLFHAFVEA GHEAGFEVTE DYNGEKQEGF 

       190        200        210        220        230        240 
GPMEQTIHNG RRWSAANAYL KPALKRPNVK LVKGLARKIV LEGKRAVGVE IEAGRSFSTI 

       250        260        270        280        290        300 
RARREVIIAA SSINSPKLLM LSGIGPAAQL KEHGIEVVAD RPGVGQNLQD HLEVYIQQEC 

       310        320        330        340        350        360 
TQPITLYSKL NLFSKAKIGA EWLFFKTGDG ATNHFESAAF LRSKAGVEYP DIQYHFLPVA 

       370        380        390        400        410        420 
IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP VIKFNYMSHE DDWADFRHCV 

       430        440        450        460        470        480 
RLTREIFGQA AFNPYRGAEI QPGAHVQSDD EIDNFIKEHV ESAFHPCGTC KMGAVDDPMA 

       490        500        510        520        530        540 
VVDAECRVIG VEGLRVADSS IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSDQEPWI 


NPRWQVSDR

A6X2G7 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools