NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Vieille C., Richardson P.;
"Complete sequence of Actinobacillus succinogenes 130Z.";
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000746; ABR74299.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001344234.1; -.

3D structure databases

ModBase

A6VMV2.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 2.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GeneID

5348169; -.

GenomeReviews

CP000746_GR; Asuc_0931.

KEGG

asu:Asuc_0931; -.

CMR

A6VMV2; Asuc_0931.

Other

ProtoNet

A6VMV2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 416`	`416`		`Gamma-glutamyl phosphate reductase.`	`PRO_1000072277`

Sequence information

Length: 416 AA [This is the length of the unprocessed precursor]

Molecular weight: 45186 Da [This is the MW of the unprocessed precursor]

CRC64: D11013433856BC4E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTNLEVMGKA ARQAAFELSQ LSAGDKNYAL QMIAEQLESQ QQQILAANAR DIDEARINGL 

        70         80         90        100        110        120 
NDAIIDRLLL TPERLRGIAN DVRHVISLAD PVGKLIDGGI LDSGLKLERI RVPVGVIGTI 

       130        140        150        160        170        180 
YEARPNVTID VASLCLKTGN AVILRGGKET RHSNRILVEV VQNALEKAGL PKTAVQAITD 

       190        200        210        220        230        240 
PDRALVMELL KLDRYVDMII PRGGAGLHAL CKQHATIPVI IGGIGVCHTF VEQSADQNRA 

       250        260        270        280        290        300 
ISVIKNAKTQ RPSTCNTLET LLIQESIAHE FLPKLAAELP VKYYADKTAY SILHHAGAEV 

       310        320        330        340        350        360 
LAVTEDDLRK EWLCTNLNVV IVQDIEAAVA HIREYGSQHS EAILTESLQL ARRFVAQVDS 

       370        380        390        400        410 
AAVYVNASTR FTDGGQFGLG AEVAVSTQKL HARGPMGLEA LTTYKWVATG DYTVRS

A6VMV2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools