NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
"Complete sequence of Methanococcus maripaludis C7.";
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT (By similarity).
CATALYTIC ACTIVITY: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420.
PATHWAY: One-carbon metabolism; methanogenesis from carbone dioxide; 5,10-methylene-H(4)MPT from 5,10-methenyl-H(4)MPT (cofactor F420 route): step 1/1 .
SIMILARITY: Belongs to the MTD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000745; ABR66431.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001330582.1; -.

3D structure databases

ModBase

A6VJ05.

Ontologies

GO:0030268;	Molecular function: methylenetetrahydromethanopterin dehydrogenase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00058; -; 1.
PBIL [Tree]

InterPro

IPR002844; Methylene_DHase.
Graphical view of domain structure.

Pfam

PF01993; MTD; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF005627; MTD; 1.

BLOCKS

A6VJ05.

Genome annotation databases

GeneID

5329191; -.

GenomeReviews

CP000745_GR; MmarC7_1368.

KEGG

mmz:MmarC7_1368; -.

CMR

A6VJ05; MmarC7_1368.

Other

ProtoNet

A6VJ05.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Methanogenesis; One-carbon metabolism; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 277`	`277`		`F420-dependent methylenetetrahydromethanopterin dehydrogenase.`	`PRO_1000007672`

Sequence information

Length: 277 AA [This is the length of the unprocessed precursor]

Molecular weight: 29879 Da [This is the MW of the unprocessed precursor]

CRC64: 663CB9074D2C14E9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVVKIGILKC GNIGMSPVVD LCLDERADRN DIDVRVLGSG AKMGPEQVEE VAKKMVEEVK 

        70         80         90        100        110        120 
PDFIVYIGPN PAAPGPKKAR EILSAGGIPT VIIGDAPGIK DKDAMAEEGL GYVLIKCDPM 

       130        140        150        160        170        180 
IGARRQFLDP VEMAMFNADV IRVLAGTGAL RVVQNAIDDM VFAVEEGKEI PLPKIVITEQ 

       190        200        210        220        230        240 
KAVDAMDFAN PYAKAKAMAA FVMAEKVADI DVKGCFMTKE MEKYIPIVAS AHEAIRYAAK 

       250        260        270 
LVDEARELEK ATDAVSRKPH AGEGKILNKC KLMAKPE

A6VJ05 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools