NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.;
"Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity).
CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1 .
SIMILARITY: Belongs to the GMC oxidoreductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000738; ABR59418.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001326253.1; -.

3D structure databases

ModBase

A6U6Y8.

Ontologies

GO:0008812;	Molecular function: choline dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00750; -; 1.
PBIL [Tree]

InterPro

IPR011533; Choline_dehydrogenase.
IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.

Pfam

PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000137; Alcohol_oxidase; 1.

TIGRFAMs

TIGR01810; betA; 1.

PROSITE

PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; 1.

BLOCKS

A6U6Y8.

Genome annotation databases

GeneID

5321398; -.

GenomeReviews

CP000738_GR; Smed_0562.

KEGG

smd:Smed_0562; -.

CMR

A6U6Y8; Smed_0562.

Other

ProtoNet

A6U6Y8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; FAD; Flavoprotein; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 549`	`549`	`Choline dehydrogenase.`	`PRO_1000046572`
`NP_BIND`	`4 33`	`30`	`FAD (Probable).`
`ACT_SITE`	`465 465`		`By similarity.`

Sequence information

Length: 549 AA [This is the length of the unprocessed precursor]

Molecular weight: 61179 Da [This is the MW of the unprocessed precursor]

CRC64: 97AF35082E32BEB7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQADFVIIGS GSAGSALAYR LSEDGANSVV VLEFGGSDVG PFIQMPAALA WPMSMNRYNW 

        70         80         90        100        110        120 
GYLSEPEPNL NNRRITAPRG KVIGGSSSIN GMVYVRGHSE DFDRWEELGA KGWAYADVLP 

       130        140        150        160        170        180 
YYKRMEHSHG GEEGWRGTDG PLHVQRGPVK NPLFHAFIEA GKQAGFEVTE DYNGSKQEGF 

       190        200        210        220        230        240 
GLMEQTTWRG RRWSAASAYL RPALKRPNVE LVRCFARKIV IENGRATGVE IERGGRTEVV 

       250        260        270        280        290        300 
RANREVIVSA SSFNSPKLLM LSGIGPAAHL QEMGIDVKAD RPGVGQNLQD HMEFYFQQVS 

       310        320        330        340        350        360 
TKPVSLYSWL PWFWQGVAGA QWLFFKRGLG ISNQFESCAF LRSAPGVKQP DIQYHFLPVA 

       370        380        390        400        410        420 
ISYDGKAAAK SHGFQVHVGY NLSKSRGDVT LRSSDPKADP VIRFNYMSHP EDWEKFRHCV 

       430        440        450        460        470        480 
RLTREIFGQK AFDLYRGPEI QPGEKVRTDE EIDAFLREHL ESAYHPCGTC KMGAKDDPMA 

       490        500        510        520        530        540 
VVDPETRVIG VDGLRVADSS IFPHITYGNL NAPSIMTGEK AADHILGKQP LARSNQEPWI 


NPRWAVSDR

A6U6Y8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools