[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.; Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the terminal reaction in meta-cleavage pathways, that is, the transformation of acetaldehyde into acetyl coenzyme A (By similarity).
CATALYTIC ACTIVITY: Acetaldehyde + CoA + NAD⁺ = acetyl-CoA + NADH.
PATHWAY: Aromatic compound metabolism; 3-phenylpropionic acid degradation .
SUBUNIT: Interacts with mhpE (By similarity).
SIMILARITY: Belongs to the acetaldehyde dehydrogenase family. MhpF subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

CP000647; ABR77546.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001335776.1; -.

3D structure databases

ModBase

A6TAC5.

Ontologies

GO:0008774;	Molecular function: acetaldehyde dehydrogenase (acetylating) activity (inferred from electronic annotation from HAMAP).
GO:0019439;	Biological process: aromatic compound catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01657; -; 1.
PBIL [Tree]

InterPro

IPR003361; Acetylald_dehydrogenase.
IPR015426; Acetylald_DHase_C.
IPR016040; NAD(P)-bd.
IPR000534; Semialdehyde_DHase_NAD-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR21123; Acetylald_dh; 1.

Pfam

PF09290; AcetDehyd-dimer; 1.
PF01118; Semialdhyde_dh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF015689; Actaldh_dh_actl; 1.

TIGRFAMs

TIGR03215; ac_ald_DH_ac; 1.

BLOCKS

A6TAC5.

Genome annotation databases

GeneID

5338832; -.

GenomeReviews

CP000647_GR; KPN78578_20850.

KEGG

kpn:KPN_02118; -.

CMR

A6TAC5; KPN78578_20850.

Other

ProtoNet

A6TAC5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 316`	`316`		`Acetaldehyde dehydrogenase.`	`PRO_0000337982`

Sequence information

Length: 316 AA [This is the length of the unprocessed precursor]

Molecular weight: 32915 Da [This is the MW of the unprocessed precursor]

CRC64: 4CFED56175429DE3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRL GVATTHEGVG 

        70         80         90        100        110        120 
GLMQMAEFAD IDFVFDATSA GAHIKNDAAL REAKPGIRVI DLTPAAIGPY CVPVVNLADN 

       130        140        150        160        170        180 
LHQGNVNMVT CGGQATIPMV AAVSRVAKVH YAEIVASIAS QSAGPGTRAN IDEFTETTSQ 

       190        200        210        220        230        240 
AIEKVGGAGK GKAIIVLNPA EPPLMMRDTV YILSELASQE AIAASIAEMA AAVQAYVPGY 

       250        260        270        280        290        300 
RLKQQVQFEV IPEDRPVNLP GVGCFSGLKT AVYLEVEGAA HYLPAYAGNL DIMTSAALAT 

       310 
AEQMAGAMHS AAGATA

A6TAC5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools