[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.; Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity).
CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1 .
SIMILARITY: Belongs to the GMC oxidoreductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000647; ABR76034.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001334264.1; -.

3D structure databases

ModBase

A6T613.

Ontologies

GO:0008812;	Molecular function: choline dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00750; -; 1.
PBIL [Tree]

InterPro

IPR011533; Choline_dehydrogenase.
IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.

Pfam

PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000137; Alcohol_oxidase; 1.

TIGRFAMs

TIGR01810; betA; 1.

PROSITE

PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; 1.

BLOCKS

A6T613.

Genome annotation databases

GeneID

5342671; -.

GenomeReviews

CP000647_GR; KPN78578_05730.

KEGG

kpn:KPN_00584; -.

CMR

A6T613; KPN78578_05730.

Other

ProtoNet

A6T613.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; FAD; Flavoprotein; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 554`	`554`	`Choline dehydrogenase.`	`PRO_1000046564`
`NP_BIND`	`4 33`	`30`	`FAD (Probable).`
`ACT_SITE`	`473 473`		`By similarity.`

Sequence information

Length: 554 AA [This is the length of the unprocessed precursor]

Molecular weight: 61550 Da [This is the MW of the unprocessed precursor]

CRC64: 004E57E23C2E06AB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQFDYIIIGA GSAGNVLATR LTEDPNTTVL LLEAGGPDYR FDFRTQMPAA LAYPLQGKRY 

        70         80         90        100        110        120 
NWAYETEPEP YMNNRRMECG RGKGLGGSSL INGMCYIRGN AMDLDNWAKE PGLEHWSYLD 

       130        140        150        160        170        180 
CLPYYRKAET RDIGPNDYHG GDGPVSVTTP KPGNNPLFEA MVEAGVQAGY PRTDDLNGYQ 

       190        200        210        220        230        240 
QEGFGPMDRT VTPQGRRAST ARGYLDQARG RPNLTIRTHA LTDHIIFAGK RAVGVEWLEG 

       250        260        270        280        290        300 
ESTIPSKATA NKEVLLCAGA IASPQILQRS GVGNPELLRQ FDIPVVHDLP GVGENLQDHL 

       310        320        330        340        350        360 
EMYLQYECKE PVSLYPALQW WNQPKIGAEW LFGGTGIGAS NQFEAGGFIR SRAEFAWPNI 

       370        380        390        400        410        420 
QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVRLK SRDPHAHPAI LFNYMSHEQD 

       430        440        450        460        470        480 
WQEFRDAIRI TREIMNQPAL DKYRGREISP GIECQSDAEL DEFVRNHAET AFHPCGTCKM 

       490        500        510        520        530        540 
GYDEMAVVDG EGRVHGLEGL RVVDASIMPQ IITGNLNATT IMIGEKMADA IRGRQPLPRS 

       550 
TATYYVAGDA PVRR

A6T613 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools