FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000712; ABQ76576.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001265760.1; -.

3D structure databases

ModBase

A5VXG6.

Ontologies

GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

BLOCKS

A5VXG6.

Genome annotation databases

GeneID

5193439; -.

GenomeReviews

CP000712_GR; Pput_0403.

KEGG

ppf:Pput_0403; -.

CMR

A5VXG6; Pput_0403.

Other

ProtoNet

A5VXG6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 251`	`251`		`Pyrroloquinoline-quinone synthase.`	`PRO_1000061675`

Sequence information

Length: 251 AA [This is the length of the unprocessed precursor]

Molecular weight: 29107 Da [This is the MW of the unprocessed precursor]

CRC64: DED244FD33C74E4C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSDALPMSPA EFEQALRAKG AYYHIHHPYH VAMYQGRATR EQIQGWVANR FYYQVNIPMK 

        70         80         90        100        110        120 
DAAILANCPD REVRREWIQR LLDHDGAPGE DGGIEAWLRL GQAVGLDPDQ LRSQELVLPG 

       130        140        150        160        170        180 
VRFAVDAYVN FARRASWQEA ASSSLTELFA PQIHQSRLDS WPQHYPWIDP AGYEYFRTRL 

       190        200        210        220        230        240 
GQARRDVEHG LAITLQHYTT RAGQERMLEI LQFKLDILWS MLDAMSMAYE LNRPPYHSVT 

       250 
QERMWHKGIT L

A5VXG6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools