ID   GABD2_MYCTA             Reviewed;         518 AA.
AC   A5U390;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   04-NOV-2008, entry version 14.
DE   RecName: Full=Putative succinate-semialdehyde dehydrogenase [NADP+] 2;
DE            Short=SSADH 2;
DE            Short=SSDH 2;
DE            EC=1.2.1.16;
GN   Name=gabD2; OrderedLocusNames=MRA_1741;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y.,
RA   Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.;
RT   "Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra,
RT   a non-pathogenic variant closely related to the well-characterized
RT   pathogenic strain H37Rv.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NADP(+)-dependent oxidation of succinate
CC       semialdehyde to succinate. Although it has succinate semialdehyde
CC       dehydrogenase activity, is likely to act physiologically on a
CC       different aldehyde(s) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(P)(+) + H(2)O =
CC       succinate + NAD(P)H.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CP000611; ABQ73490.1; -; Genomic_DNA.
DR   RefSeq; YP_001283052.1; -.
DR   GeneID; 5211890; -.
DR   GenomeReviews; CP000611_GR; MRA_1741.
DR   KEGG; mra:MRA_1741; -.
DR   GO; GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    518       Putative succinate-semialdehyde
FT                                dehydrogenase [NADP+] 2.
FT                                /FTId=PRO_0000310712.
FT   NP_BIND     232    237       NAD or NADP (By similarity).
FT   ACT_SITE    254    254       By similarity.
FT   ACT_SITE    288    288       By similarity.
SQ   SEQUENCE   518 AA;  55324 MW;  E3AC9E895EB46270 CRC64;
     MPAPSAEVFD RLRNLAAIKD VAARPTRTID EVFTGKPLTT IPVGTAADVE AAFAEARAAQ
     TDWAKRPVIE RAAVIRRYRD LVIENREFLM DLLQAEAGKA RWAAQEEIVD LIANANYYAR
     VCVDLLKPRK AQPLLPGIGK TTVCYQPKGV VGVISPWNYP MTLTVSDSVP ALVAGNAVVL
     KPDSQTPYCA LACAELLYRA GLPRALYAIV PGPGSVVGTA ITDNCDYLMF TGSSATGSRL
     AEHAGRRLIG FSAELGGKNP MIVARGANLD KVAKAATRAC FSNAGQLCIS IERIYVEKDI
     AEEFTRKFGD AVRNMKLGTA YDFSVDMGSL ISEAQLKTVS GHVDDATAKG AKVIAGGKAR
     PDIGPLFYEP TVLTNVAPEM ECAANETFGP VVSIYPVADV DEAVEKANDT DYGLNASVWA
     GSTAEGQRIA ARLRSGTVNV DEGYAFAWGS LSAPMGGMGL SGVGRRHGPE GLLKYTESQT
     IATARVFNLD PPFGIPATVW QKSLLPIVRT VMKLPGRR
//