NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.;
"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island.";
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Homogentisate + O₂ = 4-maleylacetoacetate.
COFACTOR: Iron (By similarity).
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6 .
SIMILARITY: Belongs to the homogentisate dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000675; ABQ54688.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001250034.1; -.

3D structure databases

ModBase

A5IBD8.

Ontologies

GO:0004411;	Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559;	Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0006572;	Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00334; -; 1.
PBIL [Tree]

InterPro

IPR005708; Homogentis_dOase.
Graphical view of domain structure.

PANTHER

PTHR11056; Homogentis_dOase; 1.

Pfam

PF04209; HgmA; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01015; hmgA; 1.

BLOCKS

A5IBD8.

Genome annotation databases

GeneID

5180542; -.

GenomeReviews

CP000675_GR; LPC_0710.

KEGG

lpc:LPC_0710; -.

CMR

A5IBD8; LPC_0710.

Other

ProtoNet

A5IBD8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 416`	`416`	`Homogentisate 1,2-dioxygenase.`	`PRO_1000019530`
`METAL`	`318 318`		`Iron (By similarity).`
`METAL`	`324 324`		`Iron (By similarity).`
`METAL`	`354 354`		`Iron (By similarity).`

Sequence information

Length: 416 AA [This is the length of the unprocessed precursor]

Molecular weight: 47486 Da [This is the MW of the unprocessed precursor]

CRC64: 74E1D847B1C870BA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MYLQGFGNYH HSEAVKGALP PNQNSPQHCN LGLYAEQLSG TAFTRPRHNN LRSWLYRILP 

        70         80         90        100        110        120 
TVTQGTYYPY EFNIMHSFVD EFSPNAMRWS PLYNSSQIKC DFVEGLFHIA GSPLVNTYTY 

       130        140        150        160        170        180 
YCNHSMSDKY FANNDGELLF VPYAGEIHLY TEFGKLMLSS GSIAVIPRGV KFKVEVISKE 

       190        200        210        220        230        240 
AKGYLCENSG NPLTLPQLGP IGANGLANPR HFQYPVAAFE DSGGEHTIIC KNQKKLWFTV 

       250        260        270        280        290        300 
CNHSPLNVVA WHGNYAPYCY DLSLFNTINT VSFDHPDPSI FTVLTSESEI PGVSNLDFVI 

       310        320        330        340        350        360 
FPPRWMVAEH TFRPPYFHRN YMNELMGLVY GEYDAKKEGF IPGGISIHNC MTPHGPDYES 

       370        380        390        400        410 
YEIAASQDLK PNYINSLAFM FETKDYWQVT EQAYRHPSRQ VDYLNCWQGF KVEFSQ

A5IBD8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools